Snoring increases the development of coronary artery disease: a systematic review with meta-analysis of observational studies.
Snoring increases the development of coronary artery disease: a systematic review with meta-analysis of observational studies.
复制标题
打鼾会增加冠状动脉疾病的发生：对观察性研究进行荟萃分析的系统评价。
DOI：
10.1007/s11325-021-02345-9
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发表时间：
2021
影响因子：
2.5
通讯作者：
Wang Haoran
中科院分区：
文献类型：
--
作者：
Liu Junxiang;Shao Yangzhen;Bai Jing;Shen Yafei;Chen Yifei;Liu Dongliang;Wang Haoran
目的打鼾是阻塞性睡眠呼吸暂停（obstructive sleep apnea，OSA）的主要表现之一，比OSA更为常见。大量证据表明OSA和冠状动脉疾病（CAD）之间存在强有力的关联。然而，单独打鼾是否与CAD的高风险有关尚不清楚。本研究通过荟萃分析系统回顾了观察性研究，以评估打鼾与CAD之间的联系。方法和结果我们搜索了PubMed和Embase，检索到13篇重点关注打鼾与CAD之间关系的文章。这些文章共包括151，366名参与者和9099名CAD患者。定量分析显示打鼾者患冠心病的危险性增加28%（RR：1.28，95%CI：1.13 ~ 1.45，P < 0.001）。虽然这种关联可能部分通过OSA介导，但大多数打鼾者不受呼吸暂停的影响。鉴于打鼾的高患病率和CAD的疾病负担在一般人群中，筛查打鼾可能是值得的CAD的早期预防。
PurposeSnoring is one of the cardinal presentations of obstructive sleep apnea (OSA) and is more common than OSA. Abundant evidence has suggested a robust association between OSA and coronary artery disease (CAD). However, whether or not snoring alone is related to a higher risk of CAD is unknown. This study systematically reviewed observational studies with meta-analysis to evaluate the linkage between snoring and CAD.Methods and resultsWe searched PubMed and Embase and retrieved 13 articles focusing on the relationship between snoring and CAD. These articles included a total of 151,366 participants and 9099 CAD patients. Quantitative analysis indicated that snoring was associated with a 28% (RR: 1.28, 95% CI: 1.13 to 1.45,P< 0.001) increase in the risk of developing CAD.ConclusionsSnorers are exposed to a 28% increased risk for CAD. Although the association may be partly mediated through OSA, most snorers are not affected by apnea. Given the high prevalence of snoring and the disease burden of CAD in the general population, screening for snoring may be worthwhile for the early prevention of CAD.