Accuracy and predictive features of FDG-PET/CT and CT for diagnosis of lymph node metastasis of T1 non-small-cell lung cancer manifesting as a subsolid nodule
Accuracy and predictive features of FDG-PET/CT and CT for diagnosis of lymph node metastasis of T1 non-small-cell lung cancer manifesting as a subsolid nodule
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DOI：
10.1007/s00330-012-2395-4
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发表时间：
2012-07-01
影响因子：
5.9
通讯作者：
Kim, Jung Im
中科院分区：
文献类型：
--
作者：
Lee, Sang Min;Park, Chang Min;Kim, Jung Im
回顾性分析2005年1月至2011年5月间160例经病理证实的T1期非小细胞肺癌（NSCLCs）的淋巴结（LN）分期，评价氟脱氧葡萄糖正电子发射断层扫描（FDG-PET/CT）和CT对T1期非小细胞肺癌（NSCLCs）淋巴结（LN）分期的诊断准确性和预测特征。评价FDG-PET/CT和CT对LN分期的诊断准确性。分析原发肿瘤的最大标准化摄取值（SUVmax）和CT特征，以探讨LN转移的预测因素，160例患者中有9例（5.6%）发现LN转移。在货币符号为50%的患者中，没有LN转移。FDG-PET/CT对LN分期的敏感性、特异性和准确性分别为11.1%、86.1%和81.9%; CT分别为11.1%、96.7%和91.9%。在实性部分> 50%的患者中，有无淋巴结转移的患者SUVmax、实性部分大小、实性部分比例和病变部位差异有统计学意义。多变量分析显示，SUV最大值越高，较大的实性比例和中心位置是LN转移的独立预测因子。FDG-PET/CT在T1亚实性NSCLC的淋巴结分期中几乎没有增加CT的价值。在非小细胞肺癌（NSCLC）中，欧洲淋巴结（LN）转移是重要的。欧洲正电子发射断层扫描（PET）有助于实性NSCLC的分期。CT对T1亚实性NSCLC的LN分期几乎没有帮助。在实性比例为千分之一货币符号的患者中无LN转移。
To retrospectively evaluate the diagnostic accuracy and predictive features of F-18 fluorodeoxyglucose positron emission tomography/ computed tomography (FDG-PET/CT) and CT in lymph node (LN) staging of T1 non-small-cell lung cancers (NSCLCs) manifesting as subsolid nodules.From January 2005 to May 2011, 160 patients with pathologically proven T1 subsolid NSCLCs with LN staging were included in this study. Diagnostic accuracies of FDG-PET/CT and CT for LN staging were evaluated. Maximum standardised uptake value (SUVmax) and CT features of primary tumours were evaluated to investigate predictive factors for LN metastasis.LN metastases were found in nine of the 160 patients (5.6%). No LN metastasis was present in patients with a solid proportion a parts per thousand currency sign50%. Sensitivity, specificity and accuracy of FDG-PET/CT for LN staging on a per-patient basis were 11.1%, 86.1% and 81.9%; those of CT were 11.1%, 96.7% and 91.9%. Among patients with a solid proportion > 50%, there were significant differences in SUVmax, solid portion size, solid proportion and lesion location between patients with and without LN metastasis. Multivariate analysis revealed that higher SUVmax, a larger solid proportion and central location were independent predictors of LN metastasis.FDG-PET/CT adds little value to CT in the lymph node staging of T1 subsolid NSCLCs.aEuro cent Lymph node (LN) metastases are important in non-small-cell lung cancer (NSCLC).aEuro cent Positron emission tomography (PET) helps to stage solid NSCLCs.aEuro cent FDG-PET/CT adds little to the LN staging of T1 subsolid NSCLCs.aEuro cent No LN metastasis in patients with a solid proportion a parts per thousand currency sign50%.aEuro cent LN metastasis is more common in solid and/or centrally sited tumours.