Failure to thrive: the prevalence and concurrence of anthropometric criteria in a general infant population
Failure to thrive: the prevalence and concurrence of anthropometric criteria in a general infant population
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DOI：
10.1136/adc.2005.080333
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发表时间：
2007-02-01
影响因子：
5.2
通讯作者：
Wright, C. M.
中科院分区：
文献类型：
--
作者：
Olsen, E. M.;Petersen, J.;Wright, C. M.
背景资料：幼儿期发育不良（FTT）与随后的发育迟缓有关，并被认为反映了相对营养不良。虽然FTT的概念被广泛使用，但对于具体的定义还没有达成共识，并且目前还不清楚不同的人体测量定义在多大程度上一致。目的：为了比较FTT的不同人体测量标准的患病率和并发率，并测试这些标准在检测“严重营养不良”儿童时的灵敏度和阳性预测值，方法：对6090名丹麦新生儿应用FTT的7个标准，包括年龄别低体重、低BMI、低条件性体重增加和Waterlow消瘦标准。标准进行了比较，在两个年龄组：2-6和6-11个月的life.Results：27%的婴儿符合一个或多个标准，在至少一个两个年龄组。这些标准之间的一致性一般很差，大多数儿童只根据一项标准确定。不同标准的阳性预测值范围为1%至58%。大多数单一标准要么确定了不到一半的严重营养不良病例（3%），要么包括太多，因此具有较低的阳性预测值。低体重儿童身高往往是相对tall.Conclusions：没有一个单一的测量本身似乎是足够的识别营养生长迟缓。需要进行进一步的纵向人口研究，以调查不同标准在检测严重营养不良和随后结果方面的区分能力。
Background: Failure to thrive (FTT) in early childhood is associated with subsequent developmental delay and is recognised to reflect relative undernutrition. Although the concept of FTT is widely used, no consensus exists regarding a specific definition, and it is unclear to what extent different anthropometric definitions concur.Objective: To compare the prevalence and concurrence of different anthropometric criteria for FTT and test the sensitivity and positive predictive values of these in detecting children with "significant undernutrition'', defined as the combination of slow conditional weight gain and low body mass index (BMI).Methods: Seven criteria of FTT, including low weight for age, low BMI, low conditional weight gain and Waterlow's criterion for wasting, were applied to a birth cohort of 6090 Danish infants. The criteria were compared in two age groups: 2-6 and 6-11 months of life.Results: 27% of infants met one or more criteria in at least one of the two age groups. The concurrence among the criteria was generally poor, with most children identified by only one criterion. Positive predictive values of different criteria ranged from 1% to 58%. Most single criteria identified either less than half the cases of significant undernutrition (found in 3%) or included far too many, thus having a low positive predictive value. Children with low weight for height tended to be relatively tall.Conclusions: No single measurement on its own seems to be adequate for identifying nutritional growth delay. Further longitudinal population studies are needed to investigate the discriminating power of different criteria in detecting significant undernutrition and subsequent outcomes.