Low body mass index and lymphocytopenia associate with Mycobacterium avium complex pulmonary disease in patients with rheumatoid arthritis.
Low body mass index and lymphocytopenia associate with Mycobacterium avium complex pulmonary disease in patients with rheumatoid arthritis.
复制标题
类风湿性关节炎患者的低体重指数和淋巴细胞减少与鸟分枝杆菌复合体肺部疾病相关。
DOI：
10.1080/14397595.2018.1452334
复制
发表时间：
2019
影响因子：
2.2
通讯作者：
Nanki T.
中科院分区：
文献类型：
--
作者：
Hirose W;Harigai M;Uchiyama T;Itoh K;Ishizuka T;Matsumoto M;Nanki T.
目的：类风湿关节炎（RA）患者患鸟分枝杆菌复合肺部疾病（MAC-PD）的风险增加。我们的目的是确定与RA患者MAC-PD相关的因素，并探讨其对该病诊断的临床意义。方法：根据美国胸科学会的标准，我们检查了396例RA患者是否存在MAC-PD，并对这些患者进行了三年的随访。采用多变量logistic分析选择与MAC-PD相关的因素。为了提高MAC-PD的诊断，我们基于这些因素开发了一种称为MAC-PD评分的计分系统。结果：在这项研究中，396例患者中有14例新诊断为MAC-PD。多因素分析显示，RA患者体重指数(BMI) <18.0 kg/m2和淋巴细胞计数<1500/μl与MAC-PD相关。给他们打分，加起来得出MAC-PD评分。在20例具有与MAC-PD相符的高分辨率计算机断层扫描图像的患者中，14例MAC-PD患者的得分明显高于6例无MAC-PD患者。结论：使用这些数据，以MAC-PD评分的形式，可以帮助更有选择性地确定应该考虑进行支气管镜检查的患者。
Objectives:Patients with rheumatoid arthritis (RA) are at an increased risk ofMycobacterium aviumcomplex pulmonary disease (MAC-PD). We aimed to identify factors associated with MAC-PD in RA patients, and investigate their clinical significance for diagnosis of this disease.Methods:We examined 396 patients with RA for the presence of MAC-PD, using the criteria of the American Thoracic Society and conducted three years of follow-up on these patients. Multivariate logistic analyses were employed for selecting factors associated with MAC-PD. We developed a point system based on these factors which we call MAC-PD score to improve diagnosis of MAC-PD.Results:During this study, 14 out of 396 patients were newly diagnosed with MAC-PD. Multivariate analyses revealed body mass index (BMI) <18.0 kg/m2and lymphocyte count <1500/μl were associated with MAC-PD in RA patients. Points were assigned to them and totalled to provide the MAC-PD score. Among 20 patients with high-resolution computer tomography images consistent with MAC-PD, the scores were significantly higher in 14 patients with MAC-PD than those in six patients without MAC-PD.Conclusion:Using these data, in the forms of the MAC-PD score, could help to identify patients who should be considered for bronchoscopy more selectively.