Longitudinal Alterations of Local Spontaneous Brain Activity in Parkinson's Disease
Longitudinal Alterations of Local Spontaneous Brain Activity in Parkinson's Disease
复制标题
帕金森病局部自发脑活动的纵向变化
DOI：
10.1007/s12264-017-0171-9
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发表时间：
2017
影响因子：
5.6
通讯作者：
Zhang Minming
中科院分区：
文献类型：
--
作者：
Zeng Qiaoling;Guan Xiaojun;Lun Jason C F Law Yan;Shen Zhujing;Guo Tao;Xuan Min;Gu Quanquan;Xu Xiaojun;Chen Min;Zhang Minming
我们使用静息态功能磁共振成像来评估帕金森病 (PD) 患者局部自发大脑活动在两年内的纵向变化。数据来自 23 名 PD 患者的基线和随访数据以及 27 名年龄和性别匹配的正常对照。区域均匀性（ReHo）和基于体素的形态测量（VBM）用于识别局部自发大脑活动和灰质体积的差异。随着疾病进展，我们观察到感觉运动皮层、默认模式网络和左侧小脑的 ReHo 逐渐减少，但辅助运动区、双侧颞回和海马的 ReHo 增加。此外，左侧小脑的ReHo变化率与统一帕金森病评定量表-III评分的变化率之间存在显着的正相关。 VBM 显示三组采集的灰质体积没有显着差异。我们得出的结论是，ReHo 可能是 PD 进展的合适非侵入性标志物。
We used resting-state fMRI to evaluate longitudinal alterations in local spontaneous brain activity in Parkinson’s disease (PD) over a 2-year period. Data were acquired from 23 PD patients at baseline and follow-up, and 27 age- and sex-matched normal controls. Regional homogeneity (ReHo) and voxel-based-morphometry (VBM) were used to identify differences in local spontaneous brain activity and grey matter volume. With disease progression, we observed a progressive decrease in ReHo in the sensorimotor cortex, default-mode network, and left cerebellum, but increased ReHo in the supplementary motor area, bilateral temporal gyrus, and hippocampus. Moreover, there was a significant positive correlation between the rates of ReHo change in the left cerebellum and the rates of change in the Unified Parkinson’s Disease Rating Scale-III scores. VBM revealed no significant differences in the grey matter volume among the three sets of acquisitions. We conclude that ReHo may be a suitable non-invasive marker of progression in PD.