Percutaneous mitral valve repair: A feasibility study in an ovine model of acute ischemic mitral regurgitation
Percutaneous mitral valve repair: A feasibility study in an ovine model of acute ischemic mitral regurgitation
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DOI：
10.1002/ccd.10662
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发表时间：
2003-11-01
影响因子：
2.3
通讯作者：
Oesterle, SN
中科院分区：
文献类型：
--
作者：
Liddicoat, JR;Mac Neill, BD;Oesterle, SN
瓣环成形术是外科二尖瓣修复的基石。通过将一种新型瓣环成形装置放置在患有急性缺血性二尖瓣反流的绵羊的冠状窦中，测试了基于经皮经静脉导管的二尖瓣修复方法。所有动物的二尖瓣关闭不全从 3-4+ 减少到 0-1+ (P < 0.03)。瓣环成形术通过减小间隔外侧二尖瓣环直径（插入前 30 +/- 2.1 mm 对比插入后 24 +/- 1.7 mm；P < 0.03）发挥作用。这些初步实验证明经皮二尖瓣成形术是可行的。有必要进行进一步的研究来证明这种新方法的长期安全性和有效性。
Annuloplasty is the cornerstone of surgical mitral valve repair. A percutaneous transvenous catheter-based approach for mitral valve repair was tested by placing a novel annuloplasty device in the coronary sinus of sheep with acute ischemic mitral regurgitation. Mitral regurgitation was reduced from 3-4+ to 0-1+ in all animals (P < 0.03). The annuloplasty functioned by reducing septal-lateral mitral annular diameter (30 +/- 2.1 mm preinsertion vs. 24 +/- 1.7 mm postinsertion; P < 0.03). These preliminary experiments demonstrate that percutaneous mitral annuloplasty is feasible. Further study is necessary to demonstrate long-term safety and efficacy of this novel approach.