Inspiratory muscle training improves autonomic modulation and exercise tolerance in chronic obstructive pulmonary disease subjects: A randomized-controlled trial
Inspiratory muscle training improves autonomic modulation and exercise tolerance in chronic obstructive pulmonary disease subjects: A randomized-controlled trial
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DOI：
10.1016/j.resp.2019.03.003
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发表时间：
2019-05-01
影响因子：
2.3
通讯作者：
Mostarda, Cristiano Teixeira
中科院分区：
文献类型：
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作者：
Carvalho Cutrim, Ana Lidia;Machado Duarte, Ana Amelia;Mostarda, Cristiano Teixeira
目的：我们的目的是评估定期吸气肌训练计划对慢性阻塞性肺疾病（COPD）受试者自主调节的影响，这些自主调节通过心率变异性、运动能力和呼吸功能来测量。设计：单中心对照研究，平衡随机化（两组1：1）。设置：位于巴西圣刘易斯的COPD参考医院。参与者：22名COPD受试者加入研究。干预措施：每周3次，共4周，在30%的PImax下进行吸气肌训练（IMT）。主要观察指标：肺容量和吸气压，总6分钟步行试验和心脏自主神经调节。结果：干预组显示心脏自主神经调节改善，迷走神经调节增加（总变异性和HF [ms（2）;调整的p < 0.05]）;增加呼气和吸气能力，并且在6分钟步行试验中增加距离。
Objectives: We aimed to evaluate the effect a regular inspiratory muscle training program on autonomic modulation measured by heart rate variability, exercise capacity and respiratory function in chronic obstructive pulmonary disease subjects (COPD).Design: Single-center controlled study, with balanced randomization (1:1 for two arms).Setting: A COPD reference hospital localized in Sao Luis, Brazil.Participants: 22 COPD subjects joined the study.Interventions: Three times a week for four weeks inspiratory muscle training (IMT) at 30% of PImax.Main outcome measures: Pulmonary capacities and inspiratory pressure, total six-minute walk test and, cardiac autonomic modulation.Results: The intervention group showed improvements in the cardiac autonomic modulation, with increased vagal modulation (total variability and HF [ms(2); adjusted p < 0.05]); increased expiratory and inspiratory capacities and, increased distance in the 6-min walk test.Conclusion: 12 weeks of IMT at 30% of the maximal inspiratory pressure increased cardiac autonomic modulation, expiratory and inspiratory and exercise capacity in COPD subjects.