Increased preoperative platelet count is associated with decreased survival after resection for adenocarcinorna of the pancreas
Increased preoperative platelet count is associated with decreased survival after resection for adenocarcinorna of the pancreas
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DOI：
10.1016/j.amjsurg.2004.11.014
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发表时间：
2005-03-01
影响因子：
3
通讯作者：
Shoup, M
中科院分区：
文献类型：
--
作者：
Brown, KM;Domin, C;Shoup, M
背景：血小板被认为参与肿瘤转移。然而，血小板计数与胰腺癌预后之间的关系仍未明确。
方法：对接受胰腺腺癌切除术的患者进行病历回顾。收集人口统计学资料、围手术期资料和结果数据。采用卡普兰 - 迈耶生存分析和考克斯回归分析来确定术前血小板计数对生存的影响。
结果：在1995年6月至2003年3月期间，109例（63%为男性）中位年龄为68岁（范围42 - 85岁）的患者接受了胰腺癌切除术。单因素分析表明，血小板计数、淋巴结或切缘状态以及组织学与生存相关。在多因素分析中，血小板计数升高与不良生存之间的关联仍具有显著性。
结论：术前血小板计数升高与接受胰腺癌切除术患者的不良生存结果相关。抗血小板药物值得进一步研究，以期改善这些患者的生存情况。（c）2005爱思唯尔公司。保留所有权利。
Background: Platelets are thought to participate in tumor metastasis. However, the relationship between platelet count and prognosis in pancreatic cancer remains unresolved.Methods: A chart review of patients undergoing resection for pancreatic adenocarcinoma was undertaken. Demographic, perioperative, and outcome data were collected. Kaplan-Meier survival and Cox regression analyses were used to determine the impact of preoperative platelet count on survival.Results: Between June 1995 and March 2003, 109 patients (63% male) with a median Age of 68 years (range 42 to 85 years) underwent resection for pancreatic cancer. Univariate analysis demonstrated that platelet count, lymph node or margin status, and histology were associated with survival. In multivariate analysis, the association between increased platelet count and poor survival maintained significance.Conclusions: Increased preoperative platelet count is associated with adverse survival outcome in patients undergoing resection for pancreatic cancer. Antiplatelet medications warrant further study in an attempt to improve survival in these patients. (c) 2005 Excerpta Medica, Inc. All rights reserved.