EFFECTS OF INDOMETHACIN, PROSTAGLANDIN-E2 AND PROSTAGLANDIN-F2-ALPHA ON MOUSE BLASTOCYST ATTACHMENT AND TROPHOBLASTIC OUTGROWTH INVITRO
EFFECTS OF INDOMETHACIN, PROSTAGLANDIN-E2 AND PROSTAGLANDIN-F2-ALPHA ON MOUSE BLASTOCYST ATTACHMENT AND TROPHOBLASTIC OUTGROWTH INVITRO
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DOI：
10.1016/0090-6980(89)90091-9
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发表时间：
1989-04-01
影响因子：
2.9
通讯作者：
METTLER, L
中科院分区：
文献类型：
--
作者：
CHIDA, S;METTLER, L
进行了一项研究，以调查在植入过程中的前列腺素（PG）的参与。本文观察了吲哚美辛对体外培养的小鼠囊胚附着和滋养层生长的影响。还对体外培养物进行了研究。还对补充有PGE 2和/或PGF 2 α的培养物进行了研究。沿着吲哚美辛。吲哚美辛剂量依赖性抑制囊胚附着和滋养层生长。在补充有吲哚美辛和PGE 2或PGF 2 α的培养物中，吲哚美辛的抑制作用降低。在培养物中添加所有三种物质与处理（1）adn（2），吲哚美辛的抑制被部分逆转，但仍低于对照组没有吲哚美辛。上述结果表明PGE 2和PGF 2 α均对着床有促进作用，PGF 2 α。比PGE 2更有效。
A study was performed in order to investigate the participation of prostaglandins (PGs) during implantation. The effects of indomethacin on mouse blastocyst attachment and trophoblastic outgrowth were examined in vitro. Studies were also carried out on cultures were examined in vitro. Studies were also carried out on cultures supplemented with PGE2 and/or PGF2.alpha. along with indomethacin. Blastocyst attachment and trophoblastic outgrowth were inhibited by indomethacin dose-dependency. In the cultures supplemented with indomethacinaand PGE2 or PGF2.alpha., respectively, the inhibitory effects of indomethacin were reduced. In the cultures supplemented with all three substances with treatment (1) adn (2), inhibition of indomthacin was partially reversed, but still lower than control group without indomethacin. The above results indicate that both PGE2 and PGF2.alpha. have a promoting effect on implantation, and PGF2.alpha. was more effective than PGE2.