Multivariate Metal-Organic Frameworks for Dialing-in the Binding and Programming the Release of Drug Molecules
Multivariate Metal-Organic Frameworks for Dialing-in the Binding and Programming the Release of Drug Molecules
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DOI：
10.1021/jacs.7b07392
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发表时间：
2017-10-11
影响因子：
15
通讯作者：
Deng, Hexiang
中科院分区：
文献类型：
--
作者：
Dong, Zhiyue;Sun, Yangzesheng;Deng, Hexiang
我们报告的控制客体释放配置文件拨号在理想的相互作用的客体分子和金属有机框架（MOFs）中的孔。通过与官能团类型及其在多孔结构中的比例定量相关的速率常数，可以推导出相互作用，从而可以预测和编程客体分子的释放。具体而言，在一系列具有多个官能团的稳健和介孔MOF [MIL-101（Fe）-（NH 2）（x）、MIL-101（Fe）-（C4 H4）（x）和MIL-101（Fe）-（C4 H4）（x）（NH 2）（1-x）]中研究了三种探针分子（布洛芬、罗丹明B和多柔比星）。释放速率可以调节32倍[来自MIL-101（Fe）-（NH 2）（x）的罗丹明]，并且释放峰的时间可以在40天的释放期内移动多达12天[来自MIL-101（Fe）-（C4 H4）（x）（NH 2）（1-x）的多柔比星]，这在单组分MOF对应物的物理混合物中或在其他多孔材料中都没有获得。两个前药分子（布洛芬和阿霉素）的共释放也实现了。
We report the control of guest release profiles by dialing-in desirable interactions between guest molecules and pores in metal-organic frameworks (MOFs). The interactions can derived by the rate constants that were quantitatively correlated with the type of functional group and its proportion in the porous structure; thus the release of guest molecules can be predicted and programmed. Specifically, three probe molecules (ibuprofen, rhodamine B, and doxorubicin) were studied in a series of robust and mesoporous MOFs with multiple functional groups [MIL-101(Fe)-(NH2)(x), MIL-101(Fe)-(C4H4)(x), and MIL-101(Fe)-(C4H4)(x)(NH2)(1-x)]. The release rate can be adjusted by 32-fold [rhodamine from MIL-101(Fe)-(NH2)(x)], and the time of release peak can be shifted by up to 12 days over a 40-day release period [doxorubicin from MIL-101(Fe)-(C4H4)(x)(NH2)(1-x)], which was not obtained in the physical mixture of the single component MOF counterparts nor in other porous materials. The corelease of two pro-drug molecules (ibuprofen and doxorubicin) was also achieved.