Fullerenol inhibits the cross-talk between bone marrow-derived mesenchymal stem cells and tumor cells by regulating MAPK signaling
Fullerenol inhibits the cross-talk between bone marrow-derived mesenchymal stem cells and tumor cells by regulating MAPK signaling
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富勒醇通过调节 MAPK 信号传导抑制骨髓间充质干细胞与肿瘤细胞之间的串扰
DOI：
10.1016/j.nano.2017.03.013
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发表时间：
2017-08-01
影响因子：
5.4
通讯作者：
Chen, Chunying
中科院分区：
文献类型：
--
作者：
Nie, Xin;Tang, Jinglong;Chen, Chunying
The interaction between bone marrow-derived mesenchymal stem cells (BDMSCs) and tumor cells promotes tumor proliferation and metastasis. We found that 4T1 breast cancer cells induced malignant differentiation of BDMSCs and that BDMSCs also affected the growth and metastasis of 4T1 cells. However, when the interaction between BDMSCs and 4T1 cells was attenuated or blocked by C-60(OH)(22) nanoparticles, tumor growth and metastasis were significantly suppressed. The suppression of metastasis depended on the activation of MAPK signals in the BDMSCs, whereas the underlying pathways were related to a broad range of extracellular responses and were modulated by the secretion of multiple cytokines. Interestingly, C-60(OH)(22) regulated the malignantly differentiated BDMSCs via the Erk-and p38-MAPK and its downstream NF-kappa B signal pathway, but in normal BDMSCs regulation occurred only through Erk-and p38-MAPK and not by NF-kappa B activation. This study may provide a novel mechanism for C-60(OH)(22) nanoparticles as an anti-tumor drug. (C) 2017 Elsevier Inc. All rights reserved.
