A novel class of compounds with cutaneous wound healing properties.
A novel class of compounds with cutaneous wound healing properties.
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DOI：
10.1166/jbn.2010.1157
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发表时间：
2010-10
影响因子：
2.9
通讯作者：
Zhiguo Zhou;S. Joslin;Anthony L. Dellinger;M. Ehrich;Brad Brooks;Q. Ren;U. Rodeck;R. Lenk;C. Kepley
中科院分区：
文献类型：
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作者：
Zhiguo Zhou;S. Joslin;Anthony L. Dellinger;M. Ehrich;Brad Brooks;Q. Ren;U. Rodeck;R. Lenk;C. Kepley
伤口愈合受损是一些疾病过程（如糖尿病）的主要并发症。有效的伤口愈合受到多种过程的阻碍，包括缺氧（缺氧）、炎症、感染和通过产生有害的活性氧（ROS）而产生的氧化应激。愈合伤口的固有复杂性导致了大多数针对缓慢愈合过程中涉及的单一参数的治疗的有限疗效。富勒烯是一种碳纳米球，具有广泛的生物活性。鉴于这些分子已被证明是有效的抗炎剂和抗氧化剂，我们假设富勒烯可以根据这些特性帮助伤口愈合。我们设计并合成了一组富勒烯衍生物，并通过改进的划痕实验、离体人体皮肤模型和皮肤刺激小鼠模型研究了它们加速伤口愈合的能力。几种衍生物支持细胞迁移，在人体皮肤外植体中诱导伤口愈合，并大大加快了体内伤口愈合的速度。因此，富勒烯衍生物代表了一种潜在的新型伤口愈合疗法，可能有助于伤口愈合治疗。
Impaired wound healing is a major complication underlying several disease processes (such as diabetes). Efficient wound healing is hampered by a wide variety of processes including hypoxia (oxygen deprivation), inflammation, infection, and oxidative stress through the generation of harmful reactive oxygen species (ROS). The inherent complexity of the healing wound has resulted in limited efficacy of most therapies that target single parameters involved in the slow healing processes. Fullerenes are carbon nanospheres previously shown to exhibit a wide range of biological activities. Given that these molecules have been shown to be potent anti-inflammatories and antioxidants we hypothesized that fullerenes could aid in wound healing based on these properties. We designed and synthesized a panel of fullerene derivatives and investigated their ability to accelerate wound healing using a modified scratch assay, an ex vivo human skin model, and a mouse model of skin irritation. Several derivatives supported cell migration, induced wound closure in human skin explants, and greatly accelerated the rate at which wound healing occurred in vivo. Therefore, fullerene derivatives represent a potential new class of wound healing therapies that may aid in wound healing treatment.