High levels of serum interleukin-6 are associated with disease activity in myasthenia gravis
High levels of serum interleukin-6 are associated with disease activity in myasthenia gravis
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DOI：
10.1016/j.jneuroim.2021.577634
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发表时间：
2021-06-23
影响因子：
3.3
通讯作者：
Kuwabara, Satoshi
中科院分区：
文献类型：
--
作者：
Uzawa, Akiyuki;Akamine, Hiroyuki;Kuwabara, Satoshi
重症肌无力（MG）是一种由致病性自身抗体引起的神经肌肉接头疾病。白细胞介素6（IL-6）在辅助性T细胞17（Th 17）、滤泡辅助性T细胞（Tfh）和B细胞活化以及抗体产生中起重要作用。本研究旨在评价血清IL-6水平作为抗乙酰胆碱受体（AChR）抗体阳性MG患者疾病活动性生物标志物的临床意义。在本研究中，血清IL-6水平测定93初治抗AChR抗体阳性MG患者，并与101名对照组进行比较。并分析血清IL-6水平与临床特征的相关性。抗AChR抗体阳性MG患者血清IL-6水平显著高于对照组（中位数[四分位数间距]，2.5 [1.5-8.3] pg/mL vs. 1.5 [1.5-3.2] pg/mL，P < 0.001）。血清水平与美国MG基金会临床分类相关（斯皮尔曼rho = 0.27; P < 0.01），并在免疫抑制治疗后与疾病活动平行下降（P = 0.01）。结论：IL-6参与了抗AChR抗体阳性MG的发病过程，可作为MG的治疗靶点。
Myasthenia gravis (MG), a neuromuscular junction disorder, is caused by pathogenic autoantibodies. Interleukin6 (IL-6) plays important roles in T helper 17 (Th17), T follicular helper (Tfh), and B cell activations as well as in antibody production. This study aimed to evaluate the clinical significance of serum IL-6 level as a biomarker of disease activity in patients with anti-acetylcholine receptor (AChR) antibody-positive MG. In the present study, serum IL-6 levels were measured in 93 treatment-naive patients with anti-AChR antibody-positive MG and compared with those in 101 controls. Moreover, correlations between serum IL-6 levels and clinical characteristics were analyzed. Serum IL-6 levels were significantly higher in patients with anti-AChR antibody-positive MG than in controls (median [interquartile range], 2.5 [1.5-8.3] pg/mL vs. 1.5 [1.5-3.2] pg/mL, P < 0.001). The serum levels were correlated with the MG Foundation of America clinical classification (Spearman's rho = 0.27; P < 0.01) and decreased following immunosuppressive treatment in parallel with disease activity (P = 0.01). In conclusion, IL-6 is involved in the pathogenesis of anti-AChR antibody-positive MG and could be a therapeutic target in MG.