LARYNGEAL PAPILLOMAVIRUS INFECTION DURING CLINICAL REMISSION
LARYNGEAL PAPILLOMAVIRUS INFECTION DURING CLINICAL REMISSION
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DOI：
10.1056/nejm198305263082104
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发表时间：
1983-01-01
影响因子：
158.5
通讯作者：
ABRAMSON, AL
中科院分区：
文献类型：
--
作者：
STEINBERG, BM;TOPP, WC;ABRAMSON, AL
对20例有喉乳头状瘤病史的患者的活检样本进行了Southern杂交分析，以检测是否存在人乳头瘤病毒DNA。所有检查的乳头状瘤均含有乳头状瘤病毒DNA序列。2名活动期患者的4份非受累部位样本和8份缓解期患者的样本中也含有病毒DNA。在第三例缓解期患者中未检测到人类乳头瘤病毒DNA。这些结果解释了喉乳头状瘤病即使在长期缓解后也经常复发的临床模式。
Biopsy samples from 20 patients with a history of laryngeal papillomas was analyzed by Southern blot hybridization for the presence of human papillomavirus DNA. All papillomas examined contained papillomavirus DNA sequences. Four samples from uninvolved sites in 2 patients with active disease and 8 samples from patients in remission also contained viral DNA. No human papillomavirus DNA was detected in a 3rd patient seen during remission. These results explain the clinical pattern of frequent recurrences even after long-term remission in laryngeal papillomatosis.