FcγRIV deletion reveals its central role for IgG2a and IgG2b activity in vivo
FcγRIV deletion reveals its central role for IgG2a and IgG2b activity in vivo
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DOI：
10.1073/pnas.1014515107
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发表时间：
2010-11-09
影响因子：
11.1
通讯作者：
Ravetch, Jeffrey V.
中科院分区：
文献类型：
--
作者：
Nimmerjahn, Falk;Lux, Anja;Ravetch, Jeffrey V.
细胞Fcγ受体对于体内IgG依赖的效应功能至关重要。有令人信服的证据表明，选择性激活型Fcγ受体负责单个IgG亚类的活性。因此，在FcγRIII缺陷型小鼠中不存在IgG1活性，并且一些研究表明，最具效力的IgG亚类IgG2a和IgG2b的活性可能依赖于单个或多个激活型FcγR的组合。为了研究单个激活型FcγR对IgG亚类活性的作用，我们培育了一种FcγRIV缺陷型小鼠，并表明在自身免疫和抗体依赖性细胞毒性模型中，在缺乏这种激活型Fcγ受体的情况下，多种IgG2a和IgG2b依赖的效应功能受损。
Cellular Fc gamma receptors are essential for IgG-dependent effector functions in vivo. There is convincing evidence that selective activating Fc gamma receptors are responsible for the activity of individual IgG subclasses. Thus, IgG1 activity is absent in Fc gamma RIII-deficient mice, and several studies suggest that the activity of the most potent IgG subclasses, IgG2a and IgG2b, might be dependent on either individual or a combination of activating Fc gamma Rs. To study the role of individual activating Fc gamma Rs for IgG subclass activity, we generated an Fc gamma RIV-deficient mouse and showed that a variety of IgG2a- and IgG2b- dependent effector functions are impaired in the absence of this activating Fc gamma receptor in models of autoimmunity and antibody-dependent cellular cytotoxicity.