Naltrexone pretreatment blocks microwave-induced changes in central cholinergic receptors.
Naltrexone pretreatment blocks microwave-induced changes in central cholinergic receptors.
复制标题
纳曲酮预处理可阻断微波引起的中枢胆碱能受体的变化。
DOI：
10.1002/bem.2250120105
复制
发表时间：
1991
影响因子：
1.9
通讯作者：
Guy,AW
中科院分区：
文献类型：
--
作者：
Lai,H;Carino,MA;Wen,YF;Horita,A;Guy,AW
大鼠反复暴露于脉冲圆偏振微波(2450 MHz，2-μS脉冲，频率为500pps，功率密度为1 mW/cm~2，平均全身SAR为0.6W/kg)后，中枢神经系统中M胆碱能受体的浓度出现双相变化。接受10次45分钟微波照射的大鼠海马区受体浓度升高，而接受10次20分钟微波照射的大鼠额叶皮质和海马区受体浓度下降。这些发现证实了作者实验室早期的工作，扩展到包括在每次暴露之前用麻醉性拮抗剂纳曲酮(1 mg/kg，ip)对大鼠进行预处理。药物治疗阻断了微波引起的大脑胆碱能受体的变化。这些数据进一步支持了作者的假设，即内源性阿片类药物在微波对中枢胆碱能系统的影响中发挥了作用。
Repeated exposure of rats to pulsed, circularly polarized microwaves (2,450‐MHz, 2‐μs pulses at 500 pps, power density 1 mW/cm2, at an averaged, whole‐body SAR of 0.6 W/kg) induced biphasic changes in the concentration of muscarinic cholinergic receptors in the central nervous system. An increase in receptor concentration occurred in the hippocampus of rats subjected to ten 45‐min sessions of microwave exposure, whereas a decrease in concentration was observed in the frontal cortex and hippocampus of rats exposed to ten 20‐min sessions. These findings, which confirm earlier work in the authors' laboratory, were extended to include pretreatment of rats with the narcotic antagonist naltrexone (1 mg/kg, IP) before each session of exposure. The drug treatment blocked the microwave‐induced changes in cholinergic receptors in the brain. These data further support the authors' hypothesis that endogenous opioids play a role in the effects of microwaves on central cholinergic systems.