Is depth of anesthesia, as assessed by the bispectral index, related to postoperative cognitive dysfunction and recovery?
Is depth of anesthesia, as assessed by the bispectral index, related to postoperative cognitive dysfunction and recovery?
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DOI：
10.1213/01.ane.0000228870.48028.b5
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发表时间：
2006-09-01
影响因子：
5.7
通讯作者：
Mascha, Edward J.
中科院分区：
文献类型：
--
作者：
Farag, Ehab;Chelune, Gordon J.;Mascha, Edward J.
我们在手术过程中将74名患者随机分配至较低的脑电双频指数（BIS）方案（中位数BIS，38.9）或较高的BIS方案（平均BIS，50.7）。术前和术后4-6周，使用由处理速度指数、工作记忆指数和言语记忆指数组成的认知测试组合评估患者的认知状态。低BIS组的处理速度指数为113.7 +/- 1.5（平均值+/- SE），而高BIS组为107.9 +/- 1.4（P = 0.006）。在其他两个测试电池组件中未观察到差异。因此，更深的麻醉水平与术后4-6周更好的认知功能相关，特别是在处理信息的能力方面。
We randomized 74 patients to either a lower Bispectral Index (BIS) regimen (median BIS, 38.9) or a higher BIS regimen (mean BIS, 50.7) during the surgical procedure. Preoperatively and 4-6 wk after surgery, the patients' cognitive status was assessed with a cognitive test battery consisting of processing speed index, working memory index, and verbal memory index. Processing speed index was 113.7 +/- 1.5 (mean +/- SE) in the lower BIS group versus 107.9 +/- 1.4 in the higher BIS group (P = 0.006). No difference was observed in the other two test battery components. Somewhat deeper levels of anesthesia were therefore associated with better cognitive function 4-6 wk postoperatively, particularly with respect to the ability to process information.