Long-term particulate and other air pollutants and lung function in nonsmokers
Long-term particulate and other air pollutants and lung function in nonsmokers
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DOI：
10.1164/ajrccm.158.1.9710101
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发表时间：
1998-07-01
影响因子：
24.7
通讯作者：
Enright, PL
中科院分区：
文献类型：
--
作者：
Abbey, DE;Burchette, RJ;Enright, PL
研究了自1977年以来1,391名非吸烟者的肺功能测量（肺活量测定法和呼气流量峰值不稳定性）与20年可吸入颗粒物、悬浮硫酸盐、二氧化硫、臭氧和室内颗粒物的估计环境浓度之间的关系。人群中空气污染物的差异与肺功能的下降有关。在父母患有哮喘、支气管炎、肺气肿或花粉热的男性中，当颗粒直径< 10 μ m（PM10）超过100 μ g/m(3)时，54 d/年的增加与FEV1下降7.2%相关，与预测的百分比相同，所有女性和所有男性的呼气流量峰值不稳定性分别增加0.8%和0.6%。在所有男性中，平均SO4浓度增加1.6 μ g/m(3)与FEV1下降1.5%相关，与预测的百分比相同。在父母患有哮喘、支气管炎、肺气肿或花粉热的男性中，8小时平均臭氧浓度增加23 ppb与FEV1下降6.3%相关，与预测的百分比相同。
The associations between lung function measures (spirometry and Peak expiratory flow lability) and estimated 20-yr ambient concentrations of respirable particles, suspended sulfates, sulfur dioxide, ozone, and indoor particles were studied in a sample of 1,391 nonsmokers followed since 1977. Differences in air pollutants across the population were associated with decrements of lung function. An increase of 54 d/yr when particles < 10 mu m in diameter (PM10) exceeded 100 mu g/m(3) was associated with a 7.2% decrement in FEV1, as percent of predicted, in males whose parents had asthma, bronchitis, emphysema, or hay fever and with increased peak expiratory flow lability of 0.8% for all females and 0.6% for all males. An increase in mean SO4 concentration of 1.6 mu g/m(3) was associated with a 1.5% decrement in FEV1, as percent of predicted, in all males. An increase of 23 ppb of ozone as an 8-h average was associated with a 6.3% decrement in FEV1, as percent of predicted, in males whose parents had asthma, bronchitis, emphysema, or hay fever.