Heterogeneity of Vascular Dementia: Mechanisms and Subgroups
Heterogeneity of Vascular Dementia: Mechanisms and Subgroups
复制标题
血管性痴呆的异质性：机制和亚组
DOI：
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发表时间：
1993
影响因子：
2.6
通讯作者：
K. Blennow
中科院分区：
文献类型：
--
作者：
A. Wallin;K. Blennow
血管性痴呆（vasculardementia，VAD）的主要发病途径是多发性脑梗死（multi-infarctdementia，MID）。然而，考虑到其他可能影响大脑的血管机制，如血管壁损伤（动脉粥样硬化、玻璃样变性、淀粉样血管病或血脑屏障功能障碍）、脑血管功能不全（体循环障碍、与大脑血管解剖结构相关的灌注脆弱性或自动调节障碍）和高粘滞血症，很明显MID不是唯一的VAD类别。MID的诊断应保留与脑缺血事件相关的进行性痴呆和主要与脑大动脉相关的梗死证据相结合。皮质下白质痴呆的特征是额皮质下白质病变、白质病变和小血管受累伴或不伴腔隙性/梗死-腔隙性痴呆和Binswanger病的组合-似乎是另一种重要的VAD疾病。
Today, multiple, thromboembolically generated cerebral infarcts are regarded as the main pathogenetic pathway of vascular dementia (VAD), with multi-infarct dementia (MID) as its clinical counterpart. However, taking into account other vascular mechanisms that may influence the brain, such as vessel-wall damage (atherosclerosis, hyalinosis, amyloid angiopathy, or blood-brain barrier dysfunction), cerebrovascular insufficiency (disturbance of systemic circulation, perfusion vulnerability related to the vascular anatomy of the brain, or disturbance of autoregulation), and hyperviscosity, it is evident that MID is not the only VAD category. The diagnosis of MID ought to be reserved for the combination of progressive dementia associated with cerebral ischemic events and evidence of infarction that is mainly associated with the large cerebral arteries. Subcortical white-matter dementia characterized by frontosubcortical symptomatology, white-matter lesions, and small-vessel involvement with or without lacunes/infarcts—a combination of lacunar dementia and Binswanger's disease—appears to be another important VAD disease.
影响因子：
--
作者：
BENSON, DF;CUMMINGS, JL;TSAI, SY
通讯作者：
TSAI, SY
通过超声波体积流量计测量颈动脉狭窄和痴呆患者的颈动脉血流量。
DOI：
10.1136/jnnp.48.12.1230
发表时间：
1985
期刊：
Journal of neurology, neurosurgery, and psychiatry
影响因子：
--
作者：
Uematsu,S;Folstein,MF
通讯作者：
Folstein,MF
5-羟色胺：人基底动脉中钙激活剂的来源。
影响因子：
8.3
作者：
Rusch,NJ;Chyatte,D;SundtJr,TM;Vanhoutte,PM
通讯作者：
Vanhoutte,PM