Antiplasmodial indole alkaloids from Leuconotis griffithii
Antiplasmodial indole alkaloids from Leuconotis griffithii
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DOI：
10.1007/s11418-011-0574-2
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发表时间：
2012-04-01
影响因子：
3.3
通讯作者：
Morita, Hiroshi
中科院分区：
文献类型：
--
作者：
Nugroho, Alfarius E.;Hirasawa, Yusuke;Morita, Hiroshi
本文报道了一个新的吲哚生物碱--Leucoridine A N-氧化物（1）。其结构通过NMR、MS等多种光谱手段以及化学手段进行了鉴定。吲哚生物碱对恶性疟原虫3D 7的抗疟活性。griffithii进行了调查。
A new indole alkaloid, leucoridine A N-oxide (1), consisting of two units of a strychnan type of skeleton, was isolated from the leaves of Leuconotis griffithii. Its structure was elucidated by various spectroscopic means such as NMR and MS, and also by chemical means. Antiplasmodial activity against Plasmodium falciparum 3D7 of indole alkaloids isolated from L. griffithii was investigated.