RELATIONSHIP BETWEEN GLYCEMIC CONTROL AND COLLAGEN-LINKED ADVANCED GLYCOSYLATION END-PRODUCTS IN TYPE-I DIABETES
RELATIONSHIP BETWEEN GLYCEMIC CONTROL AND COLLAGEN-LINKED ADVANCED GLYCOSYLATION END-PRODUCTS IN TYPE-I DIABETES
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DOI：
10.2337/diacare.16.5.689
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发表时间：
1993-05-01
期刊：
影响因子：
16.2
通讯作者：
CURPHEY, TJ
中科院分区：
文献类型：
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作者：
BEISSWENGER, PJ;MOORE, LL;CURPHEY, TJ
目的：评估3年期间血糖控制与晚期糖基化终产物组织水平之间的关系。肾功能衰竭、失明和全身性血管闭塞仍然是糖尿病最严重的危害。组织糖基化和AGEs被认为在这些后遗症的发展中起着重要作用，但没有关于AGEs与长期血糖控制之间关系的数据。研究设计和方法-我们研究了48名糖尿病患者。血糖控制通过平均HbA1水平测定，AGEs通过皮肤胶原蛋白的胶原酶消化酶在335/385和370/440 nm的激发/发射读数荧光测定。结果：为了评估血糖控制与AGE水平之间的关系，根据1年和3年期间的平均HbA1水平，将控制分为良好（低于或等于8.5%）、一般（低于或等于8.5%）和较差（低于或等于10%）。对1-3年每个血糖控制水平的平均AGE水平分析显示，不同血糖控制类别的AGEs差异显著（P = 0.04和0.003），最低的AGE水平与血糖控制良好相关，最高的与血糖控制不良相关。当对年龄、性别和糖尿病病程进行调整，并通过Pearson相关系数进行检验时（P = 0.02和0.008），这种关系也非常显著。结论：发现1-3年血糖控制与组织AGEs水平之间的关系表明，AGEs可以通过改善葡萄糖水平来改变并可能逆转。
OBJECTIVE - To evaluate the relationship between glycemic control over a 3-yr period and tissue levels of advanced glycosylation end products. The development of renal failure, blindness, and generalized vascular occlusion continue to be the most serious ravages of diabetes. Tissue glycosylation and AGEs are felt to play an important role in the development of these sequelae, but no data are available on the relationship between AGEs and long-term glycemic control.RESEARCH DESIGN AND METHODS - we studied 48 subjects with diabetes. Glycemic control was determined by mean levels of HbA1, and AGEs were determined on collagenase digests of skin collagen by fluorescence at excitation/emission readings of 335/385 and 370/440 nm.RESULTS - To evaluate the relationship between glycemic control and AGE levels, control was classified as good (less-than-or-equal-to 8.5%), fair (> 8.5% but less-than-or-equal-to 1 0%), or poor (> 10%) on the basis of mean HbA1 levels during 1- and 3-yr periods. Analysis of the mean AGE levels for each level of glycemic control over 1-3 yr showed that AGEs differed significantly across categories of glycemic control (P = 0.04 and 0.003), with the lowest AGE levels associated with good and the highest with poor glycemic control. The relationship also was highly significant when adjusted for age, sex, and duration of diabetes, and when examined by Pearson's correlation coefficients (P = 0.02 and 0.008).CONCLUSION- Finding a relationship between glycemic control over 1-3 yr and tissue levels of AGEs suggests that AGEs can be modified and possibly reversed by improved glucose levels.