Do generalized tonic-clonic seizures in infancy exist?
Do generalized tonic-clonic seizures in infancy exist?
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DOI：
10.1212/01.wnl.0000187125.87414.f3
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发表时间：
2005-12-13
期刊：
影响因子：
9.9
通讯作者：
Nordli, DR
中科院分区：
文献类型：
--
作者：
Korff, C;Nordli, DR
目的：了解1个月~ 2岁婴幼儿全身强直阵挛发作（GTCS）的发生率。研究方法：从2000年5月到2005年1月，我们的视频脑电图实验室共监测了2,112例患者，对77名婴儿的109次不同癫痫发作进行了回顾。排除了8例患者的8起事件，因为视频文件不足以准确确定临床特征。回顾性分析69例101次癫痫发作的临床表现和脑电图特征。结果：作者未观察到一例GTCS。四名患者的发作类似于GTCS，但对这些发作的仔细分析显示，其中三名患者为局灶性发作，第四名患者的事件顺序略有不同。结论：全身强直阵挛性癫痫发作很少，如果有的话，看到2岁以下的婴儿在三级保健儿科癫痫单位。相反，它们更常见于年龄较大的儿童，特别是在儿童和青少年的癫痫综合征中。
Objective: To determine the frequency of generalized tonic-clonic seizures (GTCS) in infants ( 1 month to 2 years). Methods: From a total of 2,112 patients monitored in our video-EEG lab from May 2000 through January 2005, 109 distinct seizures in 77 infants were reviewed. Eight events in eight patients were excluded because of video files insufficiently reliable to determine the clinical characteristics with precision. The clinical manifestations and electrographic features of the remaining 101 seizures in 69 infants were retrospectively analyzed. Results: The authors did not observe a single GTCS. Four patients had icti that resembled GTCS, but careful analysis of these episodes revealed that three of them had a focal onset and that the fourth had a slightly different sequence of events. Conclusions: Generalized tonic-clonic seizures are rarely, if ever, seen in infants younger than age 2 in a tertiary-care pediatric epilepsy unit. Instead, they more commonly occur in older children, particularly in the well-characterized epilepsy syndromes of childhood and adolescence.