MUC1 and MUC5AC mucin expression in liver fluke-associated intrahepatic cholangiocarcinoma
MUC1 and MUC5AC mucin expression in liver fluke-associated intrahepatic cholangiocarcinoma
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DOI：
10.3748/wjg.v11.i32.4939
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发表时间：
2005-08-28
影响因子：
4.3
通讯作者：
Wongkham, Sopit
中科院分区：
文献类型：
--
作者：
Boonla, Chanchai;Sripa, Banchob;Wongkham, Sopit
目的：探讨MUC1和MUC5AC在肝内胆管细胞癌(ICC)中的表达。方法：采用免疫组织化学方法检测87例经组织学证实的肝吸虫相关性肝细胞癌中粘蛋白MUC1和MUC5AC的表达。结果：52例(60%)患者同时表达MUC1和MUC5AC，31%的患者同时表达MUC1或MUC5AC，9%的患者两者均不表达。MUC1高表达与肿瘤进展显著相关，反映为血管侵犯(P
AIM: To investigate the expressions of MUC1 and MUC5AC in intrahepatic cholangiocarcinoma (ICC). Association of expressions of mucins MUC1 and MUC5AC with clinical findings, metastasis, and survival of the liver fluke-associated ICC patients was determined.METHODS: The expressions of MUC1 and MUC5AC mucins were examined by immunohistochemical staining in 87 cases of histologically-proven ICC. The expressions of mucins in relationship between clinicopathological significance and prognosis of the patients were evaluated.RESULTS: Fifty-two patients (60%) exhibited both MUC1 and MUC5AC expressions, whereas 31% expressed either MUC1 or MUC5AC, and 9% expressed neither. High MUC1 immunoreactivity displayed a significant correlation with tumor progression as reflected by vascular invasion (P