A functional magnetic resonance imaging study of bipolar disorder - State- and trait-related dysfunction in ventral prefrontal cortices
A functional magnetic resonance imaging study of bipolar disorder - State- and trait-related dysfunction in ventral prefrontal cortices
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DOI：
10.1001/archpsyc.60.6.601
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发表时间：
2003-06-01
影响因子：
--
通讯作者：
Peterson, BS
中科院分区：
文献类型：
--
作者：
Blumberg, HP;Leung, HC;Peterson, BS
背景资料：前额叶和前扣带皮层的异常与双相情感障碍的注意力、认知和冲动调节障碍有关。急性发作与这些大脑区域的功能障碍有关，而更持久的特质相关功能障碍与这些区域的体积和细胞异常有关。然而，在双相情感障碍中，前额叶区域对状态和特质障碍的相对贡献还没有被定义。我们试图描述双相情感障碍患者额叶系统的状态和特质相关功能障碍。36名双相情感障碍患者1（11例升高，10例抑郁，和15名具有正常情绪状态的受试者）和20名在利手和性别方面匹配的健康对照受试者参加了一项事件相关功能磁共振成像研究，字Stroop，以确定区域任务相关的信号changes.Results的平均百分比：信号增加Stroop任务类似地跨诊断组的分布，包括背侧前扣带回和前额叶皮质，与以前报道的激活在这项任务中。在腹侧前额叶皮层中检测到与双相情感障碍中特定情绪状态相关的信号变化，与正常情绪组相比，情绪升高组右侧的信号增加变钝（P=.005），抑郁组左侧的信号增加夸大（P=.02）。患者（与健康对照组相比）在左腹侧前额叶皮层的一个空间上不同的吻侧区域表现出钝化的激活，这与情绪状态无关（P
Background: Abnormalities in prefrontal and anterior cingulate cortices are implicated in disturbances of attention, cognition, and impulse regulation in bipolar disorder. Acute episodes have been associated with dysfunction in these brain regions, and more enduring trait-related dysfunction has been implicated by volumetric and cellular abnormalities in these regions. The relative contributions of prefrontal regions to state and trait disturbances in bipolar disorder, however, have not been defined. We sought to characterize state- and trait-related functional impairment in frontal systems in bipolar disorder.Methods: Thirty-six individuals with bipolar disorder 1 (11 with elevated, 10 with depressed, and 15 with euthymic mood states) and 20 healthy control subjects matched for handedness and sex participated in an event-related functional magnetic resonance imaging study of the color-word Stroop to determine mean percentage of regional task-related signal change.Results: Signal increased during the Stroop task similarly across diagnostic groups in a distribution that included dorsal anterior cingulate and prefrontal cortices, consistent with previously reported activations in this task. Signal changes associated with specific mood states in bipolar disorder were detected in ventral prefrontal cortex, with a blunted increase in signal on the right side in the elevated mood group (P=.005) and an exaggerated increase in signal on the left side in the depressed group (P=.02) compared with the euthymic group. Patients (vs healthy controls) demonstrated blunted activation in a spatially distinct, rostral region of left ventral prefrontal cortex that was independent of mood state (P