A multicellular systems biology model predicts epidermal morphology, kinetics and Ca2+ flow
A multicellular systems biology model predicts epidermal morphology, kinetics and Ca2+ flow
复制标题
DOI：
10.1093/bioinformatics/bti585
复制
发表时间：
2005-09-01
期刊：
影响因子：
5.8
通讯作者：
Neuber, K
中科院分区：
文献类型：
--
作者：
Grabe, N;Neuber, K
动机：系统生物学目前专注于整合细胞内网络，尽管临床上疾病主要由其组织学特征定义。例如，今天没有计算模型可以模拟水平分层表皮的形成。由于表皮是结构最复杂的上皮组织，系统生物学模型可以产生重要的见解上皮组织，其中大多数的所有人类cancers arising.Results：我们描述了一个系统的算法，能够模拟人体表皮的组织稳态，导致一个水平分层的组织与不同分化阶段的细胞。该系统预测表皮形态，组织动力学和二维流动的钙离子。预测性能的表皮与一个健康的和一个干扰的屏障进行比较与文献。该系统密切模仿有关的生理情况。
Motivation: Systems biology is currently focused on integrating intracellular networks, although clinically, diseases are largely defined by their histological features. For example, no computational model can simulate today the formation of a horizontally layered epidermis. Since the epidermis is the most complex structured epithelial tissue, systems biology models could yield important insights in epithelial tissue, in which most of all human cancers arise.Results: We describe the algorithms of a system, capable of simulating the tissue homeostasis in human epidermis leading to a horizontally layered tissue with cells of different differentiation stages. The system predicts epidermal morphology, tissue kinetics and 2D flow of Ca2+ ions. Predicted properties of an epidermis with a healthy and a disturbed barrier are compared with the literature. The system closely mimics the respecting physiological situations.