Dengue-associated maculopathy
Dengue-associated maculopathy
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DOI：
10.1001/archopht.125.4.501
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发表时间：
2007-04-01
影响因子：
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通讯作者：
Flores, John Vincent Policarpio
中科院分区：
文献类型：
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作者：
Bacsal, Kristine Enrile;Chee, Soon-Phaik;Flores, John Vincent Policarpio
目的：描述一个大型系列中登革热相关性黄斑病变的眼底表现和血管造影及光学相干断层扫描特征的临床谱。方法：我们回顾了2002年1月1日至2005年12月31日在新加坡国家眼科中心诊断为登革热黄斑病变的患者的临床记录。我们确定了41例登革热血清学证据的患者，这些患者在登革热症状发作后1个月内出现了不归因于其他疾病的眼部体征和症状。71只眼有黄斑病变。患眼的平均最佳矫正视力为20/40（范围，手部运动至20/20）。45%的眼可见视网膜内血管瘤，通常与静脉鞘有关。眼底荧光血管造影显示小静脉闭塞25%，小动脉和/或小静脉渗漏分别为3%和13%。28%的患者视网膜下出现黄色斑点。其中50%在吲哚菁绿色血管造影上显示相应的低荧光斑点。中心或旁中心暗点占63%。28例患者接受类固醇治疗。平均视力显示显着改善之间的第2周和第4周，随着眼睛的比例增加，达到最佳矫正视力的20/40或更好的跨越time.Conclusion：眼底荧光素和吲哚菁绿色血管造影，光学相干断层扫描，和视野测试是有用的工具，在诊断登革热黄斑病变。
Objective: To describe the clinical spectrum of fundus manifestations and angiographic and optical coherence tomographic features of dengue-associated maculopathy in a large series.Methods: We reviewed clinical records of patients diagnosed as having dengue maculopathy at the Singapore National Eye Centre between January 1, 2002, and December 31, 2005.Results: We identified 41 patients with serological evidence of dengue fever who had ocular signs and symptoms not attributable to other diseases within 1 month after onset of symptoms of dengue. Seventy-one eyes had maculopathy. Mean best-corrected visual acuity in the affected eye was 20/40 (range, hand motions to 20/20). Intraretinal hemorrhages were seen in 45% of eyes, usually in association with venous sheathing. Fundus fluorescein angiography demonstrated venular occlusion in 25% or arteriolar and/or venular leakage in 3% and 13%, respectively. Yellow subretinal dots were an unusual finding in 28%. Of these, 50% showed corresponding hypofluorescent spots on indocyanine green angiography. Central or paracentral scotomas were observed in 63%. Twenty-eight patients received steroid treatment. Mean visual acuity showed significant improvement between weeks 2 and 4, with an increasing proportion of eyes achieving a best-corrected visual acuity of 20/40 or better across time.Conclusion: Fundus fluorescein and indocyanine green angiography, optical coherence tomography, and visual field testing are useful tools in the diagnosis of dengue maculopathy.