Ibuprofen inhibits oral NaCl response through transmembrane channel-like 4
Ibuprofen inhibits oral NaCl response through transmembrane channel-like 4
复制标题
布洛芬通过类跨膜通道 4 抑制口服 NaCl 反应
DOI：
10.1016/j.bbrc.2021.07.082
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Asakura T
中科院分区：
文献类型：
--
作者：
Kasahara Y;Narukawa M;Nakagita T; Abe K;Misaka T;Asakura T
非甾体抗炎药，如布洛芬，已知可以改变人类的咸味感知。然而，其潜在的分子机制仍然未知。我们研究了布洛芬对NaCl刺激参与咸味检测的上皮钠通道（ENaC）和跨膜通道样4（TMC 4）的抑制作用。虽然布洛芬仅最低限度地抑制ENaC对NaCl的反应，但它显著抑制TMC 4对NaCl的反应，IC 50为1.45 mM。这些结果表明，布洛芬通过抑制TMC 4干扰咸味检测。
Nonsteroidal anti-inflammatory drugs, such as ibuprofen, are known to modify salty taste perception in humans. However, the underlying molecular mechanisms remain unknown. We investigated the inhibitory effect of ibuprofen on the NaCl stimulation of epithelium sodium channel (ENaC) and transmembrane channel-like 4 (TMC4), which are involved in salty taste detection. Although ibuprofen only minimally inhibited the response of the ENaC to NaCl, it significantly inhibited the TMC4 response to NaCl with an IC50at 1.45 mM. These results suggest that ibuprofen interferes with detection of salty taste via inhibition of TMC4.