Effect of late modulation of nitric oxide production on murine lupus
Effect of late modulation of nitric oxide production on murine lupus
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DOI：
10.1006/clin.1997.4332
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发表时间：
1997-04-01
期刊：
影响因子：
--
通讯作者：
Gilkeson, GS
中科院分区：
文献类型：
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作者：
Oates, JC;Ruiz, P;Gilkeson, GS
MRL/MpJ-Fas(lpr) （MRL-lpr）和新西兰黑/白（NZB/W）小鼠发生以自身抗体产生和肾小球肾炎为特征的自发性自身免疫性疾病，其进展与全身一氧化氮（NO）产生的增加并行。我们实验室先前发表的一项研究表明，在临床疾病发病前口服一氧化氮合酶抑制剂n - g -单甲基-l -精氨酸（NMMA）可显著降低MRL-lpr小鼠的肾脏和关节病理。为了表征小鼠SLE中一氧化氮生成的晚期调节作用，我们在两种SLE小鼠模型发病后口服NMMA和/或限制饮食精氨酸。联合NMMA和精氨酸限制后，MRL-Epr小鼠的关节病理评分降低，NZB/W小鼠的肾脏病理评分低于对照小鼠。这些结果表明，在两种SLE模型中，在发病后调节NO的产生可以降低疾病的严重程度，尽管不如发病前治疗有效。(C) 1997学术出版社。
MRL/MpJ-Fas(lpr) (MRL-lpr) and New Zealand Black/White (NZB/W) mice develop spontaneous autoimmune disease characterized by autoantibody production and glomerulonephritis that progresses in parallel with increasing systemic nitric oxide (NO) production. A previously published study from our laboratory indicated that oral administration of the nitric oxide synthase inhibitor N-G-monomethyl-L-arginine (NMMA) before the onset of clinical disease significantly decreased renal and joint pathology in MRL-lpr mice, To characterize the effect of late modulation of NO production in murine SLE, we administered oral NMMA and/or restricted dietary arginine after disease onset in two murine models of SLE. When receiving combined NMMA and arginine restriction, MRL-Epr mice had reduced joint pathology scores and NZB/W mice had lower renal pathology scores than control mice. These results indicate that modulating NO production after the onset of disease diminishes disease severity in two models of SLE, although not as effectively as treating before disease onset. (C) 1997 Academic Press.