Effort-Based Decision-Making Paradigms for Clinical Trials in Schizophrenia: Part 1—Psychometric Characteristics of 5 Paradigms.
Effort-Based Decision-Making Paradigms for Clinical Trials in Schizophrenia: Part 1—Psychometric Characteristics of 5 Paradigms.
复制标题
DOI：
10.1093/schbul/sbv089
复制
发表时间：
2015-09
影响因子：
6.6
通讯作者：
L. F. Reddy;W. Horan;D. M. Barch;Robert W. Buchanan;E. Dunayevich;James M. Gold;Naomi Lyons;S. Marder;M. Treadway;J. Wynn;Jared W. Young;Michael F. Green
中科院分区：
文献类型：
--
作者：
L. F. Reddy;W. Horan;D. M. Barch;Robert W. Buchanan;E. Dunayevich;James M. Gold;Naomi Lyons;S. Marder;M. Treadway;J. Wynn;Jared W. Young;Michael F. Green
精神分裂症阴性症状的动机缺陷特征是努力意愿受损。本研究评估了5个新的或改编的范式的心理测量学特性，以确定它们是否适合用于精神分裂症的临床试验。这项研究包括94名临床稳定的精神分裂症患者和40名健康对照者。基于努力的决策电池管理两次精神分裂症组（基线，4周重测）和一次控制组。5个范式包括1个评估认知努力，1个感知努力，3个评估身体努力。每种范例都根据（1）患者与健康对照组的差异，（2）重测信度，（3）作为重复测量的效用（即，实践效果）和（4）耐受性进行评价。这5种范式显示出不同的心理测量优势和劣势。奖励任务的努力支出显示出最好的可靠性和效用作为一个重复的措施，而抓握努力任务有显着的患者-对照组的差异，和优越的上级耐受性和管理持续时间。其他范式在目前的形式下表现出较弱的心理测量学特征。这些发现突出了在调整临床试验中使用的努力和动机范式的挑战。
Impairments in willingness to exert effort contribute to the motivational deficits characteristic of the negative symptoms of schizophrenia. The current study evaluated the psychometric properties of 5 new or adapted paradigms to determine their suitability for use in clinical trials of schizophrenia. This study included 94 clinically stable participants with schizophrenia and 40 healthy controls. The effort-based decision-making battery was administered twice to the schizophrenia group (baseline, 4-week retest) and once to the control group. The 5 paradigms included 1 that assesses cognitive effort, 1 perceptual effort, and 3 that assess physical effort. Each paradigm was evaluated on (1) patient vs healthy control group differences, (2) test-retest reliability, (3) utility as a repeated measure (ie, practice effects), and (4) tolerability. The 5 paradigms showed varying psychometric strengths and weaknesses. The Effort Expenditure for Rewards Task showed the best reliability and utility as a repeated measure, while the Grip Effort Task had significant patient-control group differences, and superior tolerability and administration duration. The other paradigms showed weaker psychometric characteristics in their current forms. These findings highlight challenges in adapting effort and motivation paradigms for use in clinical trials.