ProTherm, version 4.0: thermodynamic database for proteins and mutants
ProTherm, version 4.0: thermodynamic database for proteins and mutants
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DOI：
10.1093/nar/gkh082
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发表时间：
2004-01-01
影响因子：
14.9
通讯作者：
Sarai, A
中科院分区：
文献类型：
--
作者：
Bava, KA;Gromiha, MM;Sarai, A
ProTherm 4.0版是蛋白质和突变体的热力学数据库，包含了近14500个热力学参数的数值数据（约为第一版的450%），沿着实验方法和条件、结构、功能和文献信息。蛋白质的序列和结构信息通过蛋白质数据库、蛋白质信息资源和SWISS-PROT中的条目与ProTherm中的数据之间的链接与热力学数据相关联。我们已经从热变性法测得的变性温度数据中分离出外推温度下的吉布斯自由能变化。我们已经添加了氨基酸替换的统计数据和与每个蛋白质同源结构的链接。此外，我们还改进了搜索和显示选项，以增强通过Web界面的搜索功能。ProTherm可在http：//gibk 26上免费获得。bse.kyutech.ac.jp/jouhou/Protherm/protherm.htmi.
Release 4.0 of ProTherm, thermodynamic database for proteins and mutants, contains similar to14 500 numerical data (similar to450% of the first version) of several thermodynamic parameters along with experimental methods and conditions, and structural, functional and literature information. The sequence and structural information of proteins is connected with thermodynamic data through links between entries in Protein Data Bank, Protein Information Resource and SWISS-PROT and the data in ProTherm. We have separated the Gibbs free energy change obtained at extrapolated temperature from the data on denaturation temperature measured by the thermal denaturation method. We have added the statistics of amino acid replacements and links to homologous structures to each protein. Further, we have improved the search and display options to enhance search capability through the web interface. ProTherm is freely available at http://gibk26. bse.kyutech.ac.jp/jouhou/Protherm/protherm.htmi.