Phytanic acid: measurement of plasma concentrations by gas-liquid chromatography-mass spectrometry analysis and associations with diet and other plasma fatty acids
Phytanic acid: measurement of plasma concentrations by gas-liquid chromatography-mass spectrometry analysis and associations with diet and other plasma fatty acids
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DOI：
10.1017/s000711450782407x
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发表时间：
2008-03-01
影响因子：
3.6
通讯作者：
Key, Timothy
中科院分区：
文献类型：
--
作者：
Allen, Naomi E.;Grace, Philip B.;Key, Timothy
流行病学数据表明，富含动物性食物的饮食可能与几种癌症的风险增加有关，包括前列腺癌，结肠直肠癌和乳腺癌，但可能的机制尚不清楚。据推测，植烷酸，一种主要存在于反刍动物食物中的C20支链脂肪酸，可能参与早期癌症的发展，因为它已被证明上调α-甲基酰基辅酶A消旋酶的活性，该酶通常被发现在肿瘤细胞中与正常组织相比过度表达。然而，很少有人知道的血浆植烷酸浓度的分布或其在一般人群的饮食决定因素。本横断面研究的主要目的是确定96名年龄在20-69岁之间的肉食、乳蛋素食和纯素女性的循环植烷酸浓度，这些女性被招募到欧洲癌症与营养前瞻性调查（EPIC-Oxford）的牛津部分。平均而言，肉食者血浆植烷酸浓度的几何平均值比纯素食者高6.7倍（5-77 v. 0-86 μ mol/l; P < 0.0001），平均浓度比素食者高47%（5-77 v. 3-93 μ mol/l; P=0-016）。血浆植烷酸浓度的最强决定因素似乎是乳制品脂肪摄入量（r 0.68; P < 0.0001）;植烷酸水平与年龄或其他生活方式因素无关。这些数据表明，来自乳制品的高脂肪饮食与血浆植烷酸浓度增加有关，这可能在癌症发展中起作用。
Epidemiological data suggest that a diet rich in animal foods may be associated with an increased risk of several cancers, including cancers of the prostate, colorectum and breast, but the possible mechanism is unclear. It is hypothesised that phytanic acid, a C20 branched-chain fatty acid found predominantly in foods front ruminant animals, may be involved in early cancer development because it has been shown to up regulate activity of alpha-methylacyl-coenzyme A racemase, an enzyme commonly found to be over-expressed in tumour cells compared with normal tissue. However, little is known about the distribution of plasma phytanic acid concentrations or its dietary determinants in the general population. The primary aim of the present cross-sectional study was to determine circulating phytanic acid concentrations among ninety-six meat-eating, lacto-ovo-vegetarian and vegan women, aged 20-69 years, recruited into the Oxford component of the European Prospective Investigation into Cancer and Nutrition (EPIC-Oxford). Meat-eaters had, on average, a 6.7-fold higher geometric mean plasma phytanic acid concentration than the vegans (5-77 v. 0-86 mu mol/l; P < 0.0001) and a 47 % higher mean concentration than the vegetarians (5-77 v. 3-93 mu mol/l; P=0-016). The strongest determinant of plasma phytanic acid concentration appeared to be dairy fat intake (r 0.68; P < 0.0001); phytanic acid levels were not associated with age or other lifestyle factors. These data show that a diet high in fat from dairy products is associated with increased plasma phytanic acid concentration, which may play a role in cancer development.