Direct aperture deformation: an interfraction image guidance strategy.
Direct aperture deformation: an interfraction image guidance strategy.
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DOI：
10.1118/1.2374675
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发表时间：
2006-12
期刊：
影响因子：
3.8
通讯作者：
Yuanming Feng;C. Castro-Pareja;R. Shekhar;Cedric X. Yu
中科院分区：
文献类型：
--
作者：
Yuanming Feng;C. Castro-Pareja;R. Shekhar;Cedric X. Yu
提出了一种在体成像制导下在线校正干涉几何不确定性的新方法--直接孔径变形（DAD）。使用可变形图像配准，可以导出三维几何变换矩阵，其将计划图像集与在治疗当天采集的图像相关联。而不是重新规划或移动病人，我们使用的变形矩阵变形的治疗孔径作为一个潜在的在线校正方法。对前列腺癌患者进行了使用调强放射治疗计划的原理验证研究。介绍了DAD的方法、步骤和算法。将原始计划、重新优化计划和刚体平移计划的剂量-体积直方图与DAD计划的剂量-体积直方图进行比较。研究表明，DAD作为目标位错和变形的通用方法是可行的。与使用治疗床平移来移动患者相比，DAD能够纠正目标脱位和变形。与重新优化相比，使用DAD方案的在线校正可以在几分钟内而不是几十分钟内完成，并且速度增益将以非常小的计划质量代价。
A new scheme, called direct aperture deformation (DAD), for online correction of interfraction geometric uncertainties under volumetric imaging guidance is presented. Using deformable image registration, the three-dimensional geometric transformation matrix can be derived that associates the planning image set and the images acquired on the day of treatment. Rather than replanning or moving the patient, we use the deformation matrix to morph the treatment apertures as a potential online correction method. A proof-of-principle study using an intensity-modulated radiation therapy plan for a prostate cancer patient was conducted. The method, procedure, and algorithm of DAD are described. The dose-volume histograms from the original plan, reoptimized plan, and rigid-body translation plan are compared with the ones from the DAD plan. The study showed the feasibility of the DAD as a general method for both target dislocation and deformation. As compared with using couch translation to move the patient, DAD is capable of correcting both target dislocation and deformations. As compared with reoptimization, online correction using the DAD scheme could be completed within a few minutes rather than tens of minutes and the speed gain would be at a very small cost of plan quality.