Role of gastrin in gastrointestinal adaptation after small bowel resection.
Role of gastrin in gastrointestinal adaptation after small bowel resection.
复制标题
胃泌素在小肠切除术后胃肠适应中的作用。
DOI：
10.1152/ajpgi.1982.243.1.g16
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Johnson,LR
中科院分区：
文献类型：
--
作者：
Dembinski,AB;Johnson,LR
胃泌素是胃、近端小肠和结肠的泌酸腺区域的粘膜的营养激素。它还对胰腺有营养作用。所有这些组织在远端小肠切除后都会发生一定程度的增生。本研究通过观察前切除大鼠肠切除后这些组织的生长情况来评价胃泌素在切除后增生中的作用。胃窦切除术本身引起泌酸腺粘膜、结肠粘膜和胰腺萎缩，但对回肠粘膜没有影响。切除本身刺激生长的所有组织和显着增加血清胃泌素水平。在切除前额叶的动物中切除后，所有组织都经历了适应性反应。切除胃窦后，除结肠外，所有组织中总DNA含量的增加与胃窦完整和胃泌素水平正常的动物一样大。这些结果表明，胃泌素在胃肠道各种组织中观察到的切除后增生中不起作用。
Gastrin is a trophic hormone for the mucosa of the oxyntic gland area of the stomach, the proximal small intestine, and the colon. It also has trophic effects on the pancreas. All these tissues undergo hyperplasia to some extent following distal small bowel resection. This study evaluates the role of gastrin in postresectional hyperplasia by examining the growth of these tissues in antrectomized rats following intestinal resection. Antrectomy itself caused atrophy of the oxyntic gland mucosa, colonic mucosa, and the pancreas but had no effect on ileal mucosa. Resection by itself stimulated growth of all tissues and significantly increased serum gastrin levels. After resection in antrectomized animals, all tissues underwent an adaptational response. The increase in total DNA content after resection in antrectomized rats was as great in all tissues, except the colon, as it was in animals with intact antrums and normal gastrin levels. These results indicate that gastrin plays no role in the postresectional hyperplasia observed in the various tissues of the gastrointestinal tract.