CEREBRAL METASTASES IN PATIENTS WITH OVARIAN-CANCER TREATED WITH CHEMOTHERAPY
CEREBRAL METASTASES IN PATIENTS WITH OVARIAN-CANCER TREATED WITH CHEMOTHERAPY
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DOI：
10.1016/0090-8258(89)90515-5
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发表时间：
1989-06-01
影响因子：
4.7
通讯作者：
HARVEY, VJ
中科院分区：
文献类型：
--
作者：
HARDY, JR;HARVEY, VJ
脑转移被认为是卵巢癌的一种罕见并发症。在一系列52例接受铂类、阿霉素和环磷酰胺联合化疗的患者中，6例患者发生脑转移，发生率（11.6%）高于其他报告。脑转移患者的中位年龄与无此并发症的患者相似。脑转移瘤发生的网站首次复发的6例患者中的3例。只有一名患者在化疗前有腹膜外疾病，六名患者中有四名在化疗后获得完全缓解。脑复发发生在最初诊断卵巢癌后0、21、27、30、34和36个月以及首次联合化疗后0、9、11、19、25和29个月。中位生存期为33个月的诊断和28.5个月的首次化疗。这与整个系列30个月（首次治疗后28个月）的诊断中位生存期相比。已确定的转移灶的治疗结果较差。诊断为脑转移后的生存期为2、2、3、6、10和41 +个月。如果其他系列证实了这些发现，可能需要考虑对全身化疗后达到完全缓解的患者进行中枢神经系统放射治疗。
Cerebral metastases are considered an uncommon complication of ovarian carcinoma. In a series of 52 patients treated with platinum, Adriamycin, and cyclophosphamide combination chemotherapy, 6 patients developed cerebral metastases, an incidence (11.6%) higher than that reported by others. The median age of the patients with cerebral metastases was similar to that of patients without this complication. Cerebral metastases occurred as site of first relapse in three of six patients. Only one patient had extraperitoneal disease prior to chemotherapy and four of the six patients had attained a complete response following chemotherapy. Cerebral relapse occurred at 0, 21, 27, 30, 34, and 36 months from original diagnosis of ovarian carcinoma and 0, 9, 11, 19, 25 and 29 months following first treatment with combination chemotherapy. The median survival was 33 months from diagnosis and 28.5 months from first treatment with chemotherpay. This compares with a median survival from diagnosis for the entire series of 30 months (28 months from first treatment). The result of treatment of established metastases was poor. Survival from diagnosis of cerebral metastases was 2, 2, 3, 6, 10, and 41 + months. If other series confirm these findings consideration may need to be given to prophylatic central nervous system radiotherapy for patients achieving complete remission after systemic chemotherapy.