Associations between stress, trait negative affect, acute immune reactivity, and antibody response to hepatitis B injection in healthy young adults.
Associations between stress, trait negative affect, acute immune reactivity, and antibody response to hepatitis B injection in healthy young adults.
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DOI：
10.1037/0278-6133.20.1.4
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发表时间：
2001
期刊：
影响因子：
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通讯作者：
A. Marsland;Sheldon Cohen;B. Rabin;S. Manuck
中科院分区：
文献类型：
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作者：
A. Marsland;Sheldon Cohen;B. Rabin;S. Manuck
84名健康的研究生参与者进行了3次B型肝炎疫苗接种的标准疗程。第一次注射后5个月（第二次注射后不久），每位参与者完成心理社会测量，并抽取血液样本用于测定B型肝炎表面抗体滴度。在完成疫苗接种系列后，参与者进行了急性应激协议，包括30分钟的适应期和5分钟的评价性言语任务。在休息和任务期结束时抽血，用于评估细胞免疫指标。在第二次注射B型肝炎后评估的较低抗体应答，通过（a）高性状负面影响和（B）对PHA应答的T细胞增殖减少独立预测。这些数据提供的证据表明，特质负面影响和应激诱导的免疫功能抑制的程度可能具有临床意义。
Eighty-four healthy graduate participants were administered the standard course of 3 hepatitis B vaccinations. Five months after the first dose (shortly after the second injection), each participant completed psychosocial measures, and a blood sample was drawn for determination of hepatitis B surface antibody titer. After completion of the vaccination series, participants performed an acute stress protocol, consisting of a 30-min adaptation period and a 5-min evaluative speech task. Blood was drawn at the end of the resting and task periods for assessment of cellular immune measures. Lower antibody response, as assessed after the second hepatitis B injection, was predicted independently by (a) high trait negative affect and (b) diminished T-cell proliferation in response to PHA. These data provide evidence that trait negative affect and the magnitude of stress-induced suppression of immune function may have clinical significance.