Level of expression of E-cadherin mRNA in colorectal cancer correlates with clinical outcome.
Level of expression of E-cadherin mRNA in colorectal cancer correlates with clinical outcome.
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DOI：
10.1038/bjc.1995.119
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发表时间：
1995-03
影响因子：
8.8
通讯作者：
Hart, I R
中科院分区：
文献类型：
--
作者：
Dorudi, S;Hanby, A M;Poulsom, R;Northover, J;Hart, I R
从已知临床结果的患者中切除的一系列结直肠癌患者（n = 49），使用原位杂交法测量mRNA，分析E-cadherin的表达。存活5年及以上的患者（n = 31）的E-cadherin mRNA水平明显高于存活5年以下的患者（n = 18, P = 0.003）。这些小样本的初步结果表明，e -钙粘蛋白表达可能是结直肠癌患者的一个有用的预后标志物。
A series of colorectal carcinomas (n = 49) resected from patients with known clinical outcomes were analysed for E-cadherin expression using in situ hybridisation to measure mRNA. Patients surviving 5 years or longer (n = 31) exhibited significantly higher levels of E-cadherin mRNA than those surviving less than 5 years (n = 18, P = 0.003). These preliminary results from this small sample suggest that E-cadherin expression may be a useful prognostic marker in colorectal cancer patients.