Neuronal codes for the inhibitory control of impulsive actions in the rat infralimbic cortex
Neuronal codes for the inhibitory control of impulsive actions in the rat infralimbic cortex
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大鼠边缘皮层冲动行为抑制控制的神经元编码
DOI：
10.1016/j.bbr.2015.08.025
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发表时间：
2016
影响因子：
2.7
通讯作者：
Yoshioka M.
中科院分区：
文献类型：
--
作者：
Tsutsui-Kimura I.;Ohmura Y.;Izumi T.;Matsushima T.;Amita H.;Yamaguchi T.;Yoshida T;Yoshioka M.
冲动控制能力差是在各种精神疾病中观察到的一种使人衰弱的状况，可能是吸毒成瘾、犯罪和自杀的危险因素。大鼠边缘下皮层（IL）位于内侧前额叶皮层的腹侧，与冲动控制有关。为了阐明冲动控制的神经生理学基础，我们记录了大鼠执行3-选择连续反应时间任务（3-CSRTT）和2-选择任务（2-CT）时IL的单单位活动，这是冲动的动物模型。注射muscimol （0.1 μg /侧）使IL神经元活性失活，破坏了3-CSRTT的冲动控制。在3-CSRTT中，超过60%（38/56）的孤立IL单元与冲动控制有关，而所有单元中约有30%与注意功能有关。为了避免将运动相关单元与脉冲控制相关单元混淆，我们进一步进行了2-CT，在记录窗口期间限制动物的运动活动。超过30%（14/44）记录的IL单元与2-CT的脉冲控制有关。确定了几种类型的脉冲控制相关单元。所有单元中只有16%与muscimol实验结果相符，在行为抑制释放前立即出现短暂的放电率下降。这是第一个阐明IL中冲动控制的神经生理学基础的研究，并提出IL神经元以比以前认为的更复杂的方式控制冲动行为。
Poor impulse control is a debilitating condition observed in various psychiatric disorders and could be a risk factor for drug addiction, criminal involvement, and suicide. The rat infralimbic cortex (IL), located in the ventral portion of the medial prefrontal cortex, has been implicated in impulse control. To elucidate the neurophysiological basis of impulse control, we recorded single unit activity in the IL of a rat performing a 3-choiceserial reaction time task (3-CSRTT) and 2-choice task (2-CT), which are animal models for impulsivity. The inactivation of IL neuronal activity with an injection of muscimol (0.1 μg /side) disrupted impulse control in the 3-CSRTT. More than 60% (38/56) of isolated IL units were linked to impulse control, while approximately 30% of all units were linked to attentional function in the 3-CSRTT. To avoid confounding motor-related units with the impulse control-related units, we further conducted the 2-CT in which the animals' motor activities were restricted during recording window. More than 30% (14/44) of recorded IL units were linked to impulse control in the 2-CT. Several types of impulse control-related units were identified. Only 16% of all units were compatible with the results of the muscimol experiment, which showed a transient decline in the firing rate immediately before the release of behavioral inhibition. This is the first study to elucidate the neurophysiological basis of impulse control in the IL and to propose that IL neurons control impulsive actions in a more complex manner than previously considered.