MAGNETIC-FIELDS AND CANCER IN CHILDREN RESIDING NEAR SWEDISH HIGH-VOLTAGE POWER-LINES
MAGNETIC-FIELDS AND CANCER IN CHILDREN RESIDING NEAR SWEDISH HIGH-VOLTAGE POWER-LINES
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DOI：
10.1093/oxfordjournals.aje.a116881
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发表时间：
1993-10-01
影响因子：
5
通讯作者：
AHLBOM, A
中科院分区：
文献类型：
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作者：
FEYCHTING, M;AHLBOM, A
进行了一项病例对照研究，以检验暴露于高压电线产生的磁场会增加儿童癌症发病率的假设。研究对象为1960年至1985年期间居住在瑞典220和400千伏输电线300米范围内的16岁以下的所有人。受试者从他们进入研究基地到1985年进行了随访。通过与瑞典癌症登记处的记录联系，共确定了142例癌症病例。白血病39例，中枢神经系统肿瘤33例。从研究基地中随机选择了558名对照。通过现场测量和计算电力线产生的磁场，并考虑到距离、线路配置和负载，对暴露进行了评估。有关电力线上的历史负载的信息用于计算最接近诊断时间的一年的磁场。当使用历史计算作为儿童白血病的暴露评估时，临界点为0.1和0.2微特斯拉（muT），估计的相对风险在两个暴露水平上增加，0.2 muT及以上估计为2.7（95%置信区间（CI）1.0-6.3）;趋势p = 0.02。当上限临界点变为0.3 μ T时，相对风险为3.8（95% CI 1.4-9.3）;趋势p = 0.005。调整潜在混杂因素后，这些结果仍然存在。对于中枢神经系统肿瘤，淋巴瘤和所有儿童癌症的结合，没有支持相关性。
A case-control study was conducted to test the hypothesis that exposure to magnetic fields of the type generated by high-voltage power lines increases cancer incidence in children. The study base consisted of everyone under age 16 years who had lived on a property located within 300 meters of any of the 220 and 400 kV power lines in Sweden during the period 1960-1985. Subjects were followed from their entry into the study base through 1985. A total of 142 cancer cases were identified through a record linkage to the Swedish Cancer Registry. There were 39 leukemia and 33 central nervous system tumor cases. A total of 558 controls were selected at random from the study base. Exposure was assessed by spot measurements and by calculations of the magnetic fields generated by the power lines, taking distance, line configuration and load into account. Information about historical loads on the power lines was used to calculate the magnetic fields for the year closest in time to diagnosis. When historical calculations were used as exposure assessment for childhood leukemia with cutoff points at 0.1 and 0.2 microtesla (muT), the estimated relative risk increased over the two exposure levels and was estimated at 2.7 (95% confidence interval (CI) 1.0-6.3) for 0.2 muT and over; p for trend = 0.02. When the upper cutoff point was shifted to 0.3 muT, the relative risk was 3.8 (95% CI 1.4-9.3); p for trend = 0.005. These results persisted when adjustment for potential confounding factors was made. For central nervous system tumor, lymphoma, and all childhood cancers combined, there was no support for an association.