The impact of switching to the new global lung function initiative equations on spirometry results in the UK CF Registry
The impact of switching to the new global lung function initiative equations on spirometry results in the UK CF Registry
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DOI：
10.1016/j.jcf.2013.11.006
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发表时间：
2014-05-01
影响因子：
5.2
通讯作者：
Bilton, Diana
中科院分区：
文献类型：
--
作者：
Stanojevic, Sanja;Stocks, Janet;Bilton, Diana
背景：Quanjer等人。全球肺功能倡议(GLI)-2012年多种族、全年龄的肺活量测量参考方程式得到所有主要呼吸学会的认可，是新的黄金标准。在GLI方程被用于CF患者之前，改变那些方程的影响。方法：利用2007年至2011年提交给英国CF信托登记处的年度回顾数据，使用三个广泛使用的参考方程(Wang-Hankinson和Knudson)和新的GLI-2012方程计算预测的FEV1、FVC和FEV1/FVC的百分比。结果：总体而言，Knudson和Wang公式高估了儿科患者的预测百分比，导致更多的患者肺功能值在正常范围内。在个别患者中，切换方程的影响因患者的年龄和使用的方程而有很大差异。结论：统一的方法来解释肺功能测量将有助于在中心和国家之间进行更适当的比较。在所有年龄段使用连续的参考方程来解释纵向测量，如GLI，可能会进一步提高我们对CF肺部疾病的理解。(C)2013年欧洲囊性纤维化协会。爱思唯尔出版，版权所有。
Background: The Quanjer et al. Global Lung Function Initiative (GLI)-2012 multi-ethnic all-age reference equations for spirometry are endorsed by all major respiratory societies and are the new gold standard. Before the GLI equations are implemented for use in CF patients, the impact of changing equations from those. currently used needs to be better understood.Methods: Annual review data submitted to the UK CF Trust Registry between 2007 and 2011 were used to calculate %predicted FEV1, FVC and FEV1/FVC using three widely used reference equations (Wang-Hankinson and Knudson) and the new GLI-2012 equations.Results: Overall, Knudson and Wang equations overestimated %predicted values in paediatric patients, such that a greater proportion of patients had lung function values in the normal range. Within individual patients, the impact of switching equations varied greatly depending on the patients' age, and which equations were used.Conclusions: A unified approach to interpreting spirometric lung function measurements would help facilitate more appropriate comparison both within and between centres and countries. Interpretation of longitudinal measurements using a continuous referende equation across all-ages, like the GLI, may further improve our understanding of CF lung disease. (C) 2013 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.