Innate immunity to Toxoplasma gondii is influenced by gender and is associated with differences in interleukin-12 and gamma interferon production
Innate immunity to Toxoplasma gondii is influenced by gender and is associated with differences in interleukin-12 and gamma interferon production
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DOI：
10.1128/iai.65.3.1119-1121.1997
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发表时间：
1997-03-01
影响因子：
3.1
通讯作者：
Alexander, J
中科院分区：
文献类型：
--
作者：
Walker, W;Roberts, CW;Alexander, J
鉴于性别之间对寄生虫感染的相对易感性存在差异，本研究进一步阐明了相关机制，证明雄性 SCID 小鼠比雌性小鼠对弓形虫感染具有更强的抵抗力，并且这种差异与这些动物的先天免疫反应增强相关。雄性 SCID 小鼠表现出更长的存活时间、更低的寄生虫负担以及感染后不太严重的病理变化。这些差异的免疫学基础被证明是，这些动物更快地产生白细胞介素 12，并且在感染后早期表现出更高水平的 γ 干扰素。
Given that differences between the sexes in relative susceptibility to parasitic infections have been noted, this study further elucidates the mechanisms responsible by demonstrating that male SCID mice are more resistant than female mice to infection with Toxoplasma gondii and that this difference correlates with enhanced innate immune responses in these animals. Male SCID mice exhibited longer survival times, lower parasite burdens, and less severe pathological changes postinfection. An immunological basis for these differences is demonstrated in that these animals produced interleukin-12 more rapidly and exhibited higher levels of gamma interferon earlier postinfection.