Neural stem cells and regeneration of injured spinal cord
Neural stem cells and regeneration of injured spinal cord
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DOI：
10.1111/j.1523-1755.2005.00621.x
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发表时间：
2005-11-01
影响因子：
19.6
通讯作者：
Toyama, Y
中科院分区：
文献类型：
--
作者：
Okano, H;Okada, S;Toyama, Y
干细胞生物学的最新进展使人们对旨在使受损的中枢神经系统再生的新的治疗干预有了更多的了解。主要策略可分为两个亚组：（1）内源性神经干细胞的激活，和（2）细胞移植疗法。在这两种策略中，了解神经干细胞的维持、激活和分化的潜在机制以及随后的过程，包括分化细胞的迁移、存活和功能成熟是至关重要的。本文就近年来脊髓损伤的治疗性干预研究进展进行综述，重点介绍抗白细胞介素（IL）-6受体阻断抗体治疗脊髓损伤急性期的研究进展。
Recent progress in the stem cell biology has led much insight into new therapeutic interventions aiming for the regeneration of the damaged central nervous system. The major strategies can be classified into two subgroups: (1) activation of endogenous neural stem cells, and (2) cell transplantation therapies. In either of these strategies, it is crucial to understand the underlying mechanisms of maintenance, activation, and differentiation of neural stem cells and subsequent process, including the migration, survival, and functional maturation of differentiated cells. In this paper, we would like to summarize our recent findings on the therapeutic interventions of the injured spinal cord, especially focusing on the development of treatment for the acute phase of spinal cord injury with anti-interleukin (IL)-6 receptor blocking antibody.