ROLE OF LOPERAMIDE AND PLACEBO IN MANAGEMENT OF IRRITABLE BOWEL SYNDROME (IBS)
ROLE OF LOPERAMIDE AND PLACEBO IN MANAGEMENT OF IRRITABLE BOWEL SYNDROME (IBS)
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DOI：
10.1007/bf01296258
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发表时间：
1984-01-01
影响因子：
3.1
通讯作者：
BARENDS, D
中科院分区：
文献类型：
--
作者：
CANN, PA;READ, NW;BARENDS, D
以双盲交叉试验的形式，对28例肠易激综合征(IBS)患者在基线条件下和安慰剂和洛哌丁胺治疗5wk后的症状评分、大便数据和标准固体餐的转运进行了测量。所有患者都接受了一系列全面的诊断性调查，对补充粗麦皮(每天10-30克)的饮食没有反应。与安慰剂相比，洛哌丁胺治疗加速了胃排空(1.2±-)。0.1比1.5。+-。0.1h；P<；0.001)，并延迟双侧小肠(6.2.+-)。0.3比4.3+-0.3h；P<；0.001)和全肠道运输(56.+-)。5比42。+-4h；P<；0.01)。18名患者表示，与安慰剂相比，服用洛哌丁胺感觉更好，在随访中，其中15名患者仍然对药物的效果感到满意。与基准期相比，服用安慰剂的大多数症状都有显著改善，但其中3项[腹泻(P<；0.01)、紧迫症(P<；0.01)和白油(P<；0.05)]显示洛哌丁胺有进一步显著改善。腹泻的改善与大便重量的任何变化无关，但与大便频率(P<；0.001)、未成形大便的排出(P<；0.01)和紧迫症的发生率(P<；0.001)有关。与服用洛哌丁胺感觉不佳的组相比，紧迫感是唯一的症状，在成功组中明显更常见。
Symptom scores, stool data and the transit of a standard, solid meal were measured in 28 patients with irritable bowel syndrome (IBS) during baseline conditions and after 5 wk of treatment with placebo and loperamide, given as a flexible dosage regime in the form of a double-blind, cross-over trial. All patients had undergone a comprehensive series of diagnostic investigations and had failed to respond to dietary supplementation with coarse wheat bran (10-30 g daily). Loperamide treatment accelerated gastric emptying, compared with placebo (1.2 .+-. 0.1 vs. 1.5 .+-. 0.1 h; P < 0.001) and delayed both small bowel (6.2 .+-. 0.3 vs. 4.3 .+-. 0.3 h; P < 0.001) and whole gut transit (56 .+-. 5 vs. 42 .+-. 4 h; P < 0.01). Eighteen patients said they felt better taking loperamide compared with placebo and, at follow up, 15 of these patients remained satisfied with the effects of the drug. Most symptoms improved significantly on placebo compared with the baseline period, but 3 of these [diarrhea (P < 0.01), urgency (P < 0.01) and borborygmi (P < 0.05)] showed a further significant improvement on loperamide. Improvement in diarrhea was not associated with any change in stool weight but was associated with reductions in stool frequency (P < 0.001), passage of unformed stools (P < 0.01), and incidence of urgency (P < 0.001). Urgency was the only symptom that was significantly more common in the success group, compared with the group who did not feel better on loperamide.