Podokinetic after-rotation in Parkinson disease
Podokinetic after-rotation in Parkinson disease
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DOI：
10.1016/j.brainres.2006.10.053
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发表时间：
2007-01-12
期刊：
影响因子：
2.9
通讯作者：
Earhart, Gammon M.
中科院分区：
文献类型：
--
作者：
Hong, Minna;Perlmutter, Joel S.;Earhart, Gammon M.
在旋转平台上行走 15 分钟会导致健康受试者在失明行走时不自觉地转身。这种适应性反应称为足动后旋转 (PKAR)，它使用与自主转动相同的运动模式，表明 PKAR 和自主转动具有共同的机制。本研究的目的是确定帕金森病 (PD) 患者是否能够适应旋转平台，帕金森病是一种因转动困难而导致严重残疾的疾病。对帕金森病患者的初步测试显示，大多数人无法连续踩在旋转平台上 15 分钟。因此，我们在八名健康人身上测试了该范例的强度较低的版本。有一天，受试者在平台上连续行走 15 分钟；另一天，他们在平台上走了三趟，每次 5 分钟，中间休息 5 分钟。两次训练结束后，受试者休息 5 分钟，然后在没有视力的情况下原地行走 30 分钟，同时记录 PKAR 的旋转速度。连续和间歇方案有效地引发了强大的 PKAR。然后，我们使用 5 分钟间隔方案测试了 8 名患有 PD 的受试者和匹配的对照组，并记录了 10 分钟的 PKAR 反应。 PD组和对照组之间没有显着差异。我们的结论是，PD 受试者可以适应旋转平台并通过间歇训练发展 PKAR。未来的研究需要确定旋转平台是否可以作为康复工具来强化转动的运动模式并减轻帕金森病患者的转动困难。 (c) 2006 Elsevier B.V. 保留所有权利。
Walking on a rotating platform for 15 min causes healthy subjects to involuntarily turn when walking without vision. This adaptive response, called podokinetic after-rotation (PKAR), uses the same kinematic patterns as voluntary turning suggesting that PKAR and voluntary turning share common mechanisms. The purpose of this study is to determine whether people with Parkinson disease (PD), a condition that produces substantial disability from turning difficulties, can adapt to the rotating platform. Initial testing of people with PD revealed that most were unable to step on the rotating platform for 15 continuous minutes. We thus tested a less intense version of the paradigm in eight healthy people. On one day, subjects walked on the platform for 15 continuous minutes; on another day, they walked on the platform for three 5-minute intervals separated by 5-minute rests. After both sessions, subjects rested for 5 min then walked in place for 30 min without vision, while we recorded rotational velocity of PKAR. Continuous and interval protocols effectively elicited robust PKAR. We then tested eight subjects with PD and matched controls using the 5-minute interval protocol and recorded PKAR responses for 10 min. There were no significant differences between the PD and control groups. We conclude that PD subjects can adapt to the rotating platform and develop PKAR from interval training. Future studies are needed to determine whether the rotating platform may act as a rehabilitative tool to reinforce motor patterns for turning and alleviate turning difficulties in people with PD. (c) 2006 Elsevier B.V. All rights reserved.