Characterization of an injectable, degradable polymer for mechanical stabilization of mandibular fractures.
Characterization of an injectable, degradable polymer for mechanical stabilization of mandibular fractures.
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DOI：
10.1002/jbm.b.33216
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发表时间：
2015-04
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影响因子：
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通讯作者：
Allan M. Henslee;Diana M. Yoon;B. Lu;Joseph Yu;Andrew A Arango;Liann P Marruffo;L. Seng;T. D. Anver;H. Ather;M. Nair;Sean O Piper;N. Demian;M. Wong;F. Kasper;A. Mikos
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文献类型：
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作者：
Allan M. Henslee;Diana M. Yoon;B. Lu;Joseph Yu;Andrew A Arango;Liann P Marruffo;L. Seng;T. D. Anver;H. Ather;M. Nair;Sean O Piper;N. Demian;M. Wong;F. Kasper;A. Mikos
本研究探讨了使用可注射聚富马酸丙二醇酯（PPF）制剂用于下颌骨骨折稳定的应用。采用全析因设计和主效应分析，评估PPF：N-乙烯基吡咯烷酮（NVP，交联剂）比例和二甲基甲苯胺（DMT，促进剂）浓度对关键理化性能（包括凝固时间、最高温度、机械性能、溶胶分数和溶胀比）的影响。此外，研究了配方交联时间对力学性能和溶胀性能的影响。结果表明，将PPF：NVP比例从3：1增加到4：1或将DMT浓度从0.05 v/w %降低到0.01 v/w %，显着降低所有机械性能，并显着增加溶胶分数和溶胀比。此外，在37°C下将交联时间从1天增加到7天显著增加了所有机械性能，并且降低了溶胶分数和溶胀比。该研究进一步表明，第1天，离体稳定的兔下颌骨的弯曲刚度从传统微型接骨板固定器的1.7 ± 0.3 N/mm增加到4：1（0.05 v/w % DMT）PPF制剂的14.5 ± 4.1 N/mm。总体而言，发现本研究中测试的制剂具有适合在下颌骨骨折固定应用中进一步考虑的性质。
This study investigated the use of injectable poly(propylene fumarate) (PPF) formulations for mandibular fracture stabilization applications. A full factorial design with main effects analysis was employed to evaluate the effects of the PPF:N-vinyl pyrrolidone (NVP, crosslinking agent) ratio and dimethyl toluidine (DMT, accelerator) concentration on key physicochemical properties including setting time, maximum temperature, mechanical properties, sol fraction, and swelling ratio. Additionally, the effects of formulation crosslinking time on the mechanical and swelling properties were investigated. The results showed that increasing the PPF:NVP ratio from 3:1 to 4:1 or decreasing the DMT concentration from 0.05 to 0.01 v/w % significantly decreased all mechanical properties as well as significantly increased the sol fraction and swelling ratio. Also, increasing the crosslinking time at 37°C from 1 to 7 days significantly increased all mechanical properties and decreased both the sol fraction and swelling ratio. This study further showed that the flexural stiffness of ex vivo stabilized rabbit mandibles increased from 1.7 ± 0.3 N/mm with a traditional mini-plate fixator to 14.5 ± 4.1 N/mm for the 4:1 (0.05 v/w % DMT) PPF formulation at day 1. Overall, the formulations tested in this study were found to have properties suitable for potential further consideration in mandibular fracture fixation applications.