Elevated Serum 25(OH)-Vitamin D Levels Are Negatively Correlated with Molar-Incisor Hypomineralization
Elevated Serum 25(OH)-Vitamin D Levels Are Negatively Correlated with Molar-Incisor Hypomineralization
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DOI：
10.1177/0022034514561657
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发表时间：
2015-02-01
影响因子：
7.6
通讯作者：
Heinrich, J.
中科院分区：
文献类型：
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作者：
Kuehnisch, J.;Thiering, E.;Heinrich, J.
迄今为止，磨牙-切牙矿化低下（MIH）的确切病因尚不确定。维生素 D 在硬组织形成中起着关键作用。因此，本研究旨在分析血清 25-羟基维生素 D (25(OH)D) 状态与从慕尼黑 GINIplus 和 LISAplus 出生队列 1048 名儿童的 10 年随访中获得的牙齿健康数据之间的关系。牙科检查包括 MIH 的诊断以及乳牙和恒牙中（非）空洞龋损的记录。血清 25(OH)D 浓度取自 10 年调查的血液样本，并使用全自动模块化系统进行测量。计算了不同的逻辑回归和泊松障碍模型。 13.6% 的研究人群被诊断出 MIH。大约 16.4% 的儿童表现出与龋齿相关的缺陷 (D3-4MFS > 0)。 25(OH)D 的平均季节调整浓度为 75.8 nmol/l（标准偏差 22.0 nmol/l）。在调整性别、年龄、体重指数、父母教育程度、同等收入和电视/个人电脑 (TV/PC) 观看时间后，血清 25(OH)D 浓度增加 10 nmol/l 与 MIH 的比值比降低显着相关（OR = 0.89；P = 0.006）。此外，较高的 25(OH)D 值与受龋齿影响的恒牙数量较少相关。结论是血清 25(OH)D 浓度升高与更好的牙齿健康参数相关。
To date, the precise etiology of molar-incisor hypomineralization (MIH) is uncertain. Vitamin D plays a key role in hard tissue formation. Therefore, this study aimed to analyze the relationship between serum 25-hydroxy-vitamin D (25(OH)D) status and dental health data obtained from 1,048 children in a 10-year follow-up of the Munich GINIplus and LISAplus birth cohorts. The dental examination included the diagnosis of MIH and recording of (non-)cavitated caries lesions in primary and permanent teeth. Serum 25(OH)D concentrations were taken from blood samples of the 10-year investigation and measured with a fully automated, modular system. Different logistic regression and Poisson hurdle models were calculated. MIH was diagnosed in 13.6% of the study population. Approximately 16.4% of the children demonstrated caries-related defects (D3-4MFS > 0). The mean season-adjusted concentration of 25(OH)D was 75.8 nmol/l (standard deviation 22.0 nmol/l). After adjusting for sex, age, body mass index, parental education, equivalent income, and television/personal computer (TV/PC) viewing hours, a 10 nmol/l increase in serum 25(OH)D concentrations was significantly associated with a lower odds ratio of having MIH (OR = 0.89; P = 0.006). Furthermore, higher 25(OH)D values were associated with a lower number of caries-affected permanent teeth. It is concluded that elevated serum 25(OH)D concentrations were associated with better dental health parameters.