Host genome polymorphisms and tuberculosis infection: What we have to say?
Host genome polymorphisms and tuberculosis infection: What we have to say?
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DOI：
10.1016/j.ejcdt.2013.12.002
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发表时间：
2014-01
期刊：
影响因子：
--
通讯作者：
Mulyadi M
中科院分区：
文献类型：
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作者：
Khalilullah SA;Harapan H;Hasan NA;Winardi W;Ichsan I;Mulyadi M
多项流行病学研究表明，宿主遗传因素在结核病感染的易感性、保护性和进展中发挥着重要作用。在这里，我们回顾了一些基因多态性对结核病易感性、严重程度和发展相关途径的影响。一些国家已在结核病患者中进行了大型病例对照研究，检查基因中的单核苷酸多态性 (SNP)。天然耐药相关巨噬细胞蛋白 1 (NRAMP1)、Toll 样受体 2 (TLR2)、白细胞介素 6 (IL-6)、肿瘤坏死因子 α (TNF-α)、白细胞介素 1 受体拮抗剂 (IL-1RA)、IL-10、维生素 D 受体 (VDR)、树突状细胞特异性的多态性 对 ICAM-3 抓取非整合素 (DC-SIGN)、单核细胞趋化蛋白 1 (MCP-1)、核苷酸寡聚结合域 2 (NOD2)、干扰素-γ (IFN-γ)、诱导型一氧化氮合酶 (iNOS)、甘露糖结合凝集素 (MBL) 和表面活性剂蛋白 A (SP-A) 进行了综述。这些基因与结核病感染存在不同的相关性，并且有强有力的证据表明宿主遗传因素在结核病的易感性、严重程度和发展中发挥着关键作用。
Several epidemiology studies suggest that host genetic factors play important roles in susceptibility, protection and progression of tuberculosis infection. Here we have reviewed the implications of some genetic polymorphisms in pathways related to tuberculosis susceptibility, severity and development. Large case-control studies examining single-nucleotide polymorphisms (SNPs) in genes have been performed in tuberculosis patients in some countries. Polymorphisms in natural resistance-associated macrophage protein 1 (NRAMP1), toll-like receptor 2 (TLR2), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), interleukin-1 receptor antagonist (IL-1RA), IL-10, vitamin D receptor (VDR), dendritic cell-specific ICAM-3-grabbing non-integrin (DC-SIGN), monocyte chemoattractant protein-1 (MCP-1), nucleotide oligomerization binding domain 2 (NOD2), interferon-gamma (IFN-γ), inducible nitric oxide synthase (iNOS), mannose-binding lectin (MBL) and surfactant proteins A (SP-A) have been reviewed. These genes have been variably associated with tuberculosis infection and there is strong evidence indicating that host genetic factors play critical roles in tuberculosis susceptibility, severity and development.