Characteristics of the Clostridium difficile cell envelope and its importance in therapeutics.
Characteristics of the Clostridium difficile cell envelope and its importance in therapeutics.
复制标题
艰难梭菌细胞包膜的特征及其在治疗学中的重要性。
DOI：
10.1111/1751-7915.12372
复制
发表时间：
2017-01
影响因子：
5.7
通讯作者：
Fagan RP
中科院分区：
文献类型：
--
作者：
Kirk JA;Banerji O;Fagan RP
艰难梭菌感染（CDI）是对人类健康的一个挑战性威胁。感染发生在正常微生物群被破坏后，最常见的是通过使用抗生素。目前对CDI的治疗主要依赖于广谱抗生素万古霉素和甲硝唑，这进一步破坏了微生物群，导致频繁复发，突出了对艰难梭菌特异性抗菌剂的需求。艰难梭菌的细胞表面代表了新药开发的有希望的靶点。艰难梭菌具有高度脱乙酰化的肽聚糖细胞壁，含有独特的次级细胞壁聚合物。与细胞壁结合的是一个必需的S层，由SlpA形成，并由另外28种相关蛋白质装饰。除了S层之外，还鉴定了许多其他细胞表面蛋白，包括几种在宿主定植中起作用的蛋白。本文旨在总结我们目前对这些不同的艰难梭菌细胞表面成分及其作为治疗靶点的可行性的理解。
Clostridium difficile infection (CDI) is a challenging threat to human health. Infections occur after disruption of the normal microbiota, most commonly through the use of antibiotics. Current treatment for CDI largely relies on the broad‐spectrum antibiotics vancomycin and metronidazole that further disrupt the microbiota resulting in frequent recurrence, highlighting the need for C. difficile‐specific antimicrobials. The cell surface of C. difficile represents a promising target for the development of new drugs. C. difficile possesses a highly deacetylated peptidoglycan cell wall containing unique secondary cell wall polymers. Bound to the cell wall is an essential S‐layer, formed of SlpA and decorated with an additional 28 related proteins. In addition to the S‐layer, many other cell surface proteins have been identified, including several with roles in host colonization. This review aims to summarize our current understanding of these different C. difficile cell surface components and their viability as therapeutic targets.