Effects of adiponectin on growth and differentiation of human keratinocytes - Implication of impaired wound healing in diabetes
Effects of adiponectin on growth and differentiation of human keratinocytes - Implication of impaired wound healing in diabetes
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DOI：
10.1016/j.bbrc.2008.07.045
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发表时间：
2008-09-19
影响因子：
3.1
通讯作者：
Kakibuchi, Masao
中科院分区：
文献类型：
--
作者：
Kawai, Kenichiro;Kageyama, Akiko;Kakibuchi, Masao
伤口愈合不良是糖尿病最常见的并发症之一。脂联素是一种丰富的循环脂肪细胞源性细胞因子，对糖尿病并发疾病具有有益作用。在此，我们报告，脂联素具有调节作用的HaCaT人角质形成细胞的生长和分化。此外，脂联素以剂量依赖性方式调节角质形成细胞中TGF β亚型的表达，这意味着脂联素通过角质形成细胞分泌生长因子来调节与伤口修复相关的其他类型的细胞。TUNEL法检测结果显示脂联素可促进角质形成细胞凋亡。综上所述，本研究结果表明，脂联素对糖尿病足患者常见的角化过度的形成具有抑制作用，其应用可能有利于开发该疾病的治疗方法。(C)2008年爱思唯尔公司All rights reserved.
Impaired wound healing is one of the most common complications associated with diabetes. Adiponectin is an abundant circulating adipocyte-derived cytokine that has beneficial effects on disorders accompanying diabetes. Herein we report that adiponectin has a regulatory effect on the growth and differentiation of HaCaT human keratinocyte cells. Furthermore, adiponectin regulated the expression of TGF beta isoforms in keratinocytes in a dose-dependent manner, which implies that adiponectin modulates other types of cells related to wound repair via secretion of growth factors from keratinocytes. Moreover, TUNEL assay results revealed that adiponectin enhances apoptosis of keratmocytes. Taken together, the present results indicate that adiponectin has suppressive effects on the formation of hyperkeratosis commonly seen in patients with diabetic foot and its application may be beneficial for developing treatment for that disorder. (C) 2008 Elsevier Inc. All rights reserved.