7-Step total synthesis of (+)-EBC-329: Photoisomerisation reveals new seco-casbane family member
7-Step total synthesis of (+)-EBC-329: Photoisomerisation reveals new seco-casbane family member
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DOI：
10.1039/c7ob01400g
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发表时间：
2017-09-14
影响因子：
3.2
通讯作者：
Williams, Craig M.
中科院分区：
文献类型：
--
作者：
Berg, Timothy J. Vanden;Pinkerton, David M.;Williams, Craig M.
从澳大利亚热带雨林中分离得到第一个次卡斯班，EBC-329，以(+)-2-卡马烯为原料，经七步反应合成。这项工作不仅确定了(8R，9S)-EBC-329的绝对立体化学归属，而且通过光异构化鉴定了一个新的Seco-Casbane家族成员。
The first seco-casbane, EBC-329, isolated from the Australian rainforest, was synthesised from (+)-2-carene in seven steps. This endeavour not only established the absolute stereochemical assignment as (8R, 9S)-EBC-329, but also identified, via photo-isomerisation, a new seco-casbane family member.