Posttraumatic stress disorder and breast cancer: Risk factors and the role of inflammation and endocrine function.
Posttraumatic stress disorder and breast cancer: Risk factors and the role of inflammation and endocrine function.
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DOI：
10.1002/cncr.32934
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发表时间：
2020-07-15
期刊：
影响因子：
6.2
通讯作者：
Stevens, Jennifer S.
中科院分区：
文献类型：
--
作者：
Brown, Lauren C.;Murphy, Amy R.;Lalonde, Chloe S.;Subhedar, Preeti D.;Miller, Andrew H.;Stevens, Jennifer S.
乳腺癌诊断可能是一种改变生活和压力的经历，可能导致慢性心理健康状况，如创伤后应激障碍（PTSD）。超过三分之一的乳腺癌患者在确诊后最初被诊断为PTSD，4年后PTSD症状持续或恶化。一个新兴的文学机构指出了几个关键的环境和生物风险因素的创伤后应激障碍的幸存者乳腺癌。公认的风险因素包括有童年创伤史，非白人，肥胖，诊断时年龄较小，诊断为乳腺癌分期较高，以及治疗后时间较短。在与大脑中的恐惧回路相关的新出现的风险因素中，特别重要的两个途径是压力驱动的炎症途径激活和抗内分泌治疗的长期影响。这些在压力暴露期间和之后的中枢和外周反应很重要，因为恐惧和焦虑的增加会导致PTSD的维持和更糟糕的患者结局。鉴于与创伤后应激障碍相关的不良结果和女性乳腺癌的高患病率，有必要进行更多的研究来确定乳腺癌后创伤后应激障碍风险增加的女性，以减少诊断数量并减轻这种慢性心理健康状况的负面影响。
A breast cancer diagnosis can be a life-changing and stressful experience that can lead to chronic mental health conditions such as posttraumatic stress disorder (PTSD). Greater than one-third of patients initially diagnosed with PTSD after a diagnosis of breast cancer continue to have persistent or worsening PTSD symptoms after 4 years. An emerging body of literature has indicated several key environmental and biological risk factors for PTSD among survivors of breast cancer. Well-recognized risk factors include having a history of childhood trauma, being nonwhite, obesity, younger age at the time of diagnosis, diagnosis with a higher stage of breast cancer, and short time since treatment. Of the emerging risk factors related to fear circuitry in the brain, 2 pathways of particular importance are the stress-driven activation of inflammatory pathways and the long-term effect of antiendocrine therapies. These central and peripheral responses during and after stress exposure are important because increased fear and anxiety can lead to the maintenance of PTSD and worse patient outcomes. Given the poor outcomes associated with PTSD and the high prevalence of breast cancer in women, more research to identify those women at heightened risk of PTSD after breast cancer is warranted to reduce the number of diagnoses and lessen the negative impact of this chronic mental health condition.
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影响因子：
4.2
作者：
ANDERSEN, BL;KARLSSON, JA;TEWFIK, HH
通讯作者：
TEWFIK, HH
影响因子：
6.2
作者：
Chan, Caryn Mei Hsien;Ng, Chong Guan;Meyer, Fremonta
通讯作者：
Meyer, Fremonta
影响因子：
3.7
作者：
Derntl B;Windischberger C;Robinson S;Lamplmayr E;Kryspin-Exner I;Gur RC;Moser E;Habel U
通讯作者：
Habel U
DOI：
10.1177/2470547017704763
发表时间：
2017-03
期刊：
Chronic stress (Thousand Oaks, Calif.)
影响因子：
--
作者：
Abdallah CG;Geha P
通讯作者：
Geha P
DOI：
10.1007/s10880-007-9083-6
发表时间：
2007-12-01
影响因子：
2.2
作者：
Cordova, Matthew J.;Giese-Davis, Janine;Spiegel, David
通讯作者：
Spiegel, David